CAJ | 학술논문

目的探讨肾络通治疗以蛋白尿为主的IgA肾病的临床疗效.方法将120例以蛋白尿为主的IgA肾病患者随机分为治疗组、对照组.在基础治疗基础上,治疗组予肾络通方,对照组予洛丁新,均治疗12个月,观察治疗前后两组疗效和中医症候积分、肾小球滤过率(GFR)、血肌酐(Scr)、24 h尿蛋白定量、血浆清蛋白(ALB)等指标的变化情况.结果两组疗效比较差异有统计学意义(P＜0.01),治疗后两组中医症状积分比较差异有统计学意义(P＜0.01).治疗组治疗后24 h尿蛋白定量降低、ALB升高,与治疗前比较差异有统计学意义(P＜0.05);与对照组比较24 h尿蛋白定量、ALB差异亦均有统计学意义(P＜0.05).结论肾络通具有改善患者症状、降低蛋白尿、保护肾功能的作用.
목적 탐토신락통치료이단백뇨위주적IgA신병적림상료효.방법 장120례이단백뇨위주적IgA신병환자수궤분위치료조、대조조.재기출치료기출상,치료조여신락통방,대조조여락정신,균치료12개월,관찰치료전후량조료효화중의증후적분、신소구려과솔(GFR)、혈기항(Scr)、24 h뇨단백정량、혈장청단백(ALB)등지표적변화정황.결과 량조료효비교차이유통계학의의(P＜0.01),치료후량조중의증상적분비교차이유통계학의의(P＜0.01).치료조치료후24 h뇨단백정량강저、ALB승고,여치료전비교차이유통계학의의(P＜0.05);여대조조비교24 h뇨단백정량、ALB차이역균유통계학의의(P＜0.05).결론 신락통구유개선환자증상、강저단백뇨、보호신공능적작용.
Objective To investigate the therapeutic effects of a self-made prescription Shenluotong in treating IgA nephropathy patients with clinical presentation of prevailing proteinuria.Methods Totally 120 IgA nephropathy patients whose main clinical presentation was proteinuria were randomly divided as trial and control groups.The patients were given,besides the basic treatment,Shenluotong in the trial group,and Lotensin in the control group for 12 months.The effects,symptom scores in Chinese medicine,and indices of glomerular filtration rate (GFR),serum creatinine (Scr),quantity of 24 h urinary protein,and plasma albumin (ALB) were observed before and after the treatment.Results The trial group was better than the control group in effect (P＜0.01);and so was in symptom score after treatment (P＜0.01).After treatment the quantity of 24 h urinary protein was decreased and ALB level was increased in the trial group (P＜0.05);and there were significant differences as compared with the control group (P＜0.05).Conclusion The Shenluotong can improve the symptom,reduce proteinuria,and protect renal function for IgA nephropathy patients.