CAJ | 학술논문

孕激素效应由孕激素核受体或膜受体介导.研究证实,淋巴细胞、自然杀伤细胞,单核细胞等多种免疫细胞表达孕激素核受体或膜受体.孕激素可直接通过孕激素受体或间接通过孕激素诱导的封闭因子发挥免疫调节效应,诱导Th2细胞反应、抑制Th1细胞反应,增加B淋巴细胞不对称抗体合成,抑制自然杀伤细胞、单核细胞的杀伤活性.孕激素血清水平下降、孕激素受体表达调节障碍,导致其免疫调节作用降低,参与系统性红斑狼疮发病及病情进展.
잉격소효응유잉격소핵수체혹막수체개도.연구증실,림파세포、자연살상세포,단핵세포등다충면역세포표체잉격소핵수체혹막수체.잉격소가직접통과잉격소수체혹간접통과잉격소유도적봉폐인자발휘면역조절효응,유도Th2세포반응、억제Th1세포반응,증가B림파세포불대칭항체합성,억제자연살상세포、단핵세포적살상활성.잉격소혈청수평하강、잉격소수체표체조절장애,도치기면역조절작용강저,삼여계통성홍반랑창발병급병정진전.
The effects of progesterone are mediated by its nuclear or membrane receptors, which have been identified in a variety of immune cells including lymphocytes, natural killer cells, monocytes, etc. Recently, a growing body of evidence has confirmed the immunomodulatory activities of progesterone, including induction of T helper 2 (Th2) cell response, inhibition of Th1 cell reaction, promotion of asymmetric antibody synthesis by B cells, suppression of killing activity of natural killer cells and monocytes, which are mediated directly by its receptors or indirectly by progesterone-induced blocking factors. Lower level of progesterone in sera and impaired progesterone receptor expression have been identified in systemic lupus erythematosus, which may result in an attenuation in the immunomodulatory effect of progesterone, and contribute to the initiation and progression of systemic lupus erythematosus.