CAJ | 학술논문

人类诱导多能性干细胞(iPS细胞)的出现被誉为生命科学领域里新的里程碑,它建立了一种全新的、相对易操作而较稳定的体细胞核重编程方法,在生物学基础研究和临床应用方面具有潜在的价值;然而,iPS细胞的高癌变率和极低的重编程效率大大限制了它的应用.目前iPS细胞技术正在被不断完善,就iPS细胞的研究历程及在诱导iPS细胞上的最新研究进展进行综述.
인류유도다능성간세포(iPS세포)적출현피예위생명과학영역리신적리정비,타건립료일충전신적、상대역조작이교은정적체세포핵중편정방법,재생물학기출연구화림상응용방면구유잠재적개치;연이,iPS세포적고암변솔화겁저적중편정효솔대대한제료타적응용.목전iPS세포기술정재피불단완선,취iPS세포적연구역정급재유도iPS세포상적최신연구진전진행종술.
The induced pluripotent stem cells(iPS cells) were regarded as a milestone of life sciences,which originated a relatively easy-to-use and more stable somatic cell nuclear reprogramming method, having apotential value in basic research of biology and clinical application. However, its applications were limited by high carcinogenic rate and low efficiency of reprogramming. Currently, iPS cell technology is being continuously improved. This article reviewed the history and the latest research progress in iPS cells.