中华消化外科杂志
中華消化外科雜誌
중화소화외과잡지
CHINESE JOURNAL OF DIGESTIVE SURGERY
2009年
5期
338-340
,共3页
王聪%孙益红%沈振斌%汪学非%阴忆青%方勇%秦净%秦新裕
王聰%孫益紅%瀋振斌%汪學非%陰憶青%方勇%秦淨%秦新裕
왕총%손익홍%침진빈%왕학비%음억청%방용%진정%진신유
胃肿瘤%早期%淋巴结转移%预后
胃腫瘤%早期%淋巴結轉移%預後
위종류%조기%림파결전이%예후
Gastric neoplasms,early%Lymph node metastasis%Prognosis
目的 探讨早期胃癌患者临床病理因素与预后之间的关系,为制定合理的治疗方案提供帮助.方法 回顾性分析2002年1月至2007年10月复旦大学附属中山医院收治的459例接受D2手术的早期胃癌患者的临床资料.Kaplan-Meier法计算生存率,Log-rank检验进行单因素分析,Cox回归模型分析年龄、性别、肿瘤直径、大体类型、分化程度、浸润深度、淋巴管浸润、淋巴结转移数目对预后的影响.结果 肿瘤直径、分化程度、浸润深度、淋巴管浸润和淋巴结转移数目影响早期胃癌患者预后(χ~2=8.476,6.210,4.014,14.197,55.027,P<0.05).是否有淋巴结转移是影响早期胃癌预后的独立危险因素,且淋巴结转移数目越多,对预后的影响越大.结论 淋巴结转移是影响早期胃癌预后最为重要的因素,适度地施行淋巴结清扫有重要的意义,对于存在淋巴结转移高危因素的患者更应谨慎地施行微创手术.
目的 探討早期胃癌患者臨床病理因素與預後之間的關繫,為製定閤理的治療方案提供幫助.方法 迴顧性分析2002年1月至2007年10月複旦大學附屬中山醫院收治的459例接受D2手術的早期胃癌患者的臨床資料.Kaplan-Meier法計算生存率,Log-rank檢驗進行單因素分析,Cox迴歸模型分析年齡、性彆、腫瘤直徑、大體類型、分化程度、浸潤深度、淋巴管浸潤、淋巴結轉移數目對預後的影響.結果 腫瘤直徑、分化程度、浸潤深度、淋巴管浸潤和淋巴結轉移數目影響早期胃癌患者預後(χ~2=8.476,6.210,4.014,14.197,55.027,P<0.05).是否有淋巴結轉移是影響早期胃癌預後的獨立危險因素,且淋巴結轉移數目越多,對預後的影響越大.結論 淋巴結轉移是影響早期胃癌預後最為重要的因素,適度地施行淋巴結清掃有重要的意義,對于存在淋巴結轉移高危因素的患者更應謹慎地施行微創手術.
목적 탐토조기위암환자림상병리인소여예후지간적관계,위제정합리적치료방안제공방조.방법 회고성분석2002년1월지2007년10월복단대학부속중산의원수치적459례접수D2수술적조기위암환자적림상자료.Kaplan-Meier법계산생존솔,Log-rank검험진행단인소분석,Cox회귀모형분석년령、성별、종류직경、대체류형、분화정도、침윤심도、림파관침윤、림파결전이수목대예후적영향.결과 종류직경、분화정도、침윤심도、림파관침윤화림파결전이수목영향조기위암환자예후(χ~2=8.476,6.210,4.014,14.197,55.027,P<0.05).시부유림파결전이시영향조기위암예후적독립위험인소,차림파결전이수목월다,대예후적영향월대.결론 림파결전이시영향조기위암예후최위중요적인소,괄도지시행림파결청소유중요적의의,대우존재림파결전이고위인소적환자경응근신지시행미창수술.
Objective To investigate the relationship between various clinicopatholngic factors and prognosis of early gastric cancer. Methods The clinical data of 459 patients with early gastric cancer who had undergone gastrectomy combined with extended (D2) lymphadenectomy at Zhongshan Hospital from January 2002 to October 2007 were retrospectively analyzed. Survival was calculated using the Kaplan-Meier method, and clinicopathologic factors such as age, sex, tumor size, gross morphology, tumor differentiation, depth of invasion, lymphatic vessels involvement and lymph node metastasis were analyzed using the Cox regression model. Univariate analysis was done by Log-rank test. Results Univariate analysis demonstrated that tumor size and differentiation, depth of invasion, lymphatic vessels involvement and lymph node metastasis significantly affected survival in patients with early gastric cancer (χ~2 = 8.476, 6.210, 4.014, 14. 197, 55.027, P < 0.05). The status of lymph node metastasis was an independent predictor of survival in patients with early gastric cancer, and the more metastatic lymph nodes detected, the greater the influence on the prognosis. Conclusions Lymph node metastasis is the most important factor influencing the prognosis of early gastric cancer. Appropriate lymph node dissection is necessary, especially for patients with risk factors associated with lymph node metastasis.
