CAJ | 학술논문

14例新生儿糖尿病(neonatal diabetes mellitus)入选,比较胰岛素(n=5)和格列本脲(n=9)的疗效.扩增6例患儿KCNJ11、ABCC8、INS基因并测序.共发现2例存在ABCC8基因突变,1例KCNJ11基因突变,1例为INS基因突变,1例为6q24甲基化减低,1例突变基因不清.9例新生儿糖尿病格列本脲治疗者8例血糖控制良好(88.9%).5例采用胰岛素治疗后均失访或死亡.提示新生儿糖尿病胰岛素治疗依从性差,格列本脲可有效降低血糖.
14례신생인당뇨병(neonatal diabetes mellitus)입선,비교이도소(n=5)화격렬본뇨(n=9)적료효.확증6례환인KCNJ11、ABCC8、INS기인병측서.공발현2례존재ABCC8기인돌변,1례KCNJ11기인돌변,1례위INS기인돌변,1례위6q24갑기화감저,1례돌변기인불청.9례신생인당뇨병격렬본뇨치료자8례혈당공제량호(88.9%).5례채용이도소치료후균실방혹사망.제시신생인당뇨병이도소치료의종성차,격렬본뇨가유효강저혈당.
Fourteen neonatal diabetes mellitus(NDM)patients were recruited. 9 patients were treated with glyburide and the other 5 with insulin. ABCC8, KCNJ11, and INS genes were sequenced in 6 of them. Gene mutations were found in 2, 1, and 1 cases in these genes, respectively. One case with 6q24 hypomethylation and another without known mutation were also found. 8 out of 9 patients treated with glyburide reached euglycemia(88.9%). The other 5 patients with insulin therapy either died or lost contact. The results suggest that glyburide therapy is effective in neonatal diabetes mellitus, while insulin therapy may contribute to poor compliance.