中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
1期
10-12
,共3页
冠状动脉粥样硬化性心脏病%高敏C反应蛋白%易损斑块%血管内超声
冠狀動脈粥樣硬化性心髒病%高敏C反應蛋白%易損斑塊%血管內超聲
관상동맥죽양경화성심장병%고민C반응단백%역손반괴%혈관내초성
Coronary artery disease%High sensitivity C-reactive protein%Vulnerable plaque%Intravascular unltrasound
目的 探讨冠心病患者冠状动脉粥样硬化斑块性质及偏心性,与高敏C反应蛋白(hs-CRP)的相关性,评价hs-CR在预测冠状动脉易损斑块中的临床价值.方法 冠心病患者104例,其中稳定型心绞痛(SA)亚组28例、不稳定型心绞痛(UA)亚组54例、急性心肌梗死(AMI)亚组22例.所有患者均行冠状动脉造影术.对其中单支病变患者行血管内超声(IVUS)检查,以明确其冠状动脉粥样硬化斑块的性质和偏心性.另外选择冠状动脉造影正常者20例为对照组.所有患者同时采用乳胶增强免疫比浊法测定血清中hs-CRP的浓度.结果 ①AMI组、UA组、SA组和NS组血清hs-CRP水平,分别为(7.25±4.26)、(3.12±1.83)、(1.27±0.78)和(0.54±0.22)mg/L,两两比较,差异均有统计学意义(P＜0.01).②软斑块组(42例)纤维斑块组(13例)、钙化斑块组(12例)血清hs-CRP水平分别为(4.25±1.64)、(2.57±1.28)、(1.27±0.53)mg/L,差异有统计学意义(P＜0.01).向心性斑块组(19例)和偏心性斑块组血清hs-CRP水平分别为(2.03±1.76)mg/L与(3.58±2.37)mg/L,差异有统计学意义(P＜0.05).结论 hs-CRP参与了冠心病的发生发展,可作为冠状动脉病变程度及病情变化的预测因子,辅助冠心病的诊疗.血清hs-CRP水平有可能间接反映斑块的性质及其偏心程度,有助于判断斑块的易损性.
目的 探討冠心病患者冠狀動脈粥樣硬化斑塊性質及偏心性,與高敏C反應蛋白(hs-CRP)的相關性,評價hs-CR在預測冠狀動脈易損斑塊中的臨床價值.方法 冠心病患者104例,其中穩定型心絞痛(SA)亞組28例、不穩定型心絞痛(UA)亞組54例、急性心肌梗死(AMI)亞組22例.所有患者均行冠狀動脈造影術.對其中單支病變患者行血管內超聲(IVUS)檢查,以明確其冠狀動脈粥樣硬化斑塊的性質和偏心性.另外選擇冠狀動脈造影正常者20例為對照組.所有患者同時採用乳膠增彊免疫比濁法測定血清中hs-CRP的濃度.結果 ①AMI組、UA組、SA組和NS組血清hs-CRP水平,分彆為(7.25±4.26)、(3.12±1.83)、(1.27±0.78)和(0.54±0.22)mg/L,兩兩比較,差異均有統計學意義(P＜0.01).②軟斑塊組(42例)纖維斑塊組(13例)、鈣化斑塊組(12例)血清hs-CRP水平分彆為(4.25±1.64)、(2.57±1.28)、(1.27±0.53)mg/L,差異有統計學意義(P＜0.01).嚮心性斑塊組(19例)和偏心性斑塊組血清hs-CRP水平分彆為(2.03±1.76)mg/L與(3.58±2.37)mg/L,差異有統計學意義(P＜0.05).結論 hs-CRP參與瞭冠心病的髮生髮展,可作為冠狀動脈病變程度及病情變化的預測因子,輔助冠心病的診療.血清hs-CRP水平有可能間接反映斑塊的性質及其偏心程度,有助于判斷斑塊的易損性.
목적 탐토관심병환자관상동맥죽양경화반괴성질급편심성,여고민C반응단백(hs-CRP)적상관성,평개hs-CR재예측관상동맥역손반괴중적림상개치.방법 관심병환자104례,기중은정형심교통(SA)아조28례、불은정형심교통(UA)아조54례、급성심기경사(AMI)아조22례.소유환자균행관상동맥조영술.대기중단지병변환자행혈관내초성(IVUS)검사,이명학기관상동맥죽양경화반괴적성질화편심성.령외선택관상동맥조영정상자20례위대조조.소유환자동시채용유효증강면역비탁법측정혈청중hs-CRP적농도.결과 ①AMI조、UA조、SA조화NS조혈청hs-CRP수평,분별위(7.25±4.26)、(3.12±1.83)、(1.27±0.78)화(0.54±0.22)mg/L,량량비교,차이균유통계학의의(P＜0.01).②연반괴조(42례)섬유반괴조(13례)、개화반괴조(12례)혈청hs-CRP수평분별위(4.25±1.64)、(2.57±1.28)、(1.27±0.53)mg/L,차이유통계학의의(P＜0.01).향심성반괴조(19례)화편심성반괴조혈청hs-CRP수평분별위(2.03±1.76)mg/L여(3.58±2.37)mg/L,차이유통계학의의(P＜0.05).결론 hs-CRP삼여료관심병적발생발전,가작위관상동맥병변정도급병정변화적예측인자,보조관심병적진료.혈청hs-CRP수평유가능간접반영반괴적성질급기편심정도,유조우판단반괴적역손성.
Objective To observe the serum level changes of high-sensitivity C-reactive protein in every group patients with Coronary artery disease (CAD), to observe the conrrelation between atherosclerotic plaque and serum levels of hs-CRP and to explore the role of hs-CRP in pathogenesy and therapy. Methods One hundred and four patients ( male 66, female 38 ) with CAD were enrolled in this study. These patients included stable angina (SA) (28), unstable angina (UA) (54) and acute myocardium infarction(22). All patients underwent coronary angiography. Intravascular ultrasound (IVUS) was performed in single-artery lesion patients. In addition, 20 patients with normal CAG served as control. Serum hs-CRP level of all patients was measured by emulsion reinforced immunoturbidimetry (ITM). Results Serum levels of hs-CRP are statistically different in AMI, UA, SA and NS groups (P＜0.01). Serum levels of hs-CRP were statistically higher in soft plaque group than those in fibrous plaque group and calcified plaque group (P＜0.01). In fibrous plaque group, serum levels of hs-CRP were significantly higher than those in calcified plaque group respectively. Conclusions hs-CRP plays an important role in the development of CAD and can be considered as a predict factor in the diagnosis of CAD. Serum levels of hs-CRP is related to some plaque characters such as eccentricity and vulnerability.
