CAJ | 학술논문

目的探讨胚胎发育不良性神经上皮肿瘤(DNT)伴药物难治性癫痫患者的外科手术治疗方法.方法回顾性分析了第三军医大学新桥医院神经外科采用外科手术治疗14例此类患者的经验.术前和术中均进行致痫灶定位,术中在切除肿瘤的同时一并处理肿瘤外致痫灶.结果 14例患者肿瘤均得到全切,未行放疗和化疗,无肿瘤复发及恶性转化.11例患者癫痫发作得到完全控制(Engel Ⅰ级),2例患者稀少发作(Engel Ⅱ级),1例患者术后仍有频繁癫痫发作,再次手术切除肿瘤周围致痫灶后癫痫得到完全控制.结论 DNT应当按照皮质发育障碍来处理,除切除肿瘤外,积极处理肿瘤外致痫灶可获得较佳的癫痫控制结果.
목적 탐토배태발육불량성신경상피종류(DNT)반약물난치성전간환자적외과수술치료방법.방법 회고성분석료제삼군의대학신교의원신경외과채용외과수술치료14례차류환자적경험.술전화술중균진행치간조정위,술중재절제종류적동시일병처리종류외치간조.결과 14례환자종류균득도전절,미행방료화화료,무종류복발급악성전화.11례환자전간발작득도완전공제(Engel Ⅰ급),2례환자희소발작(Engel Ⅱ급),1례환자술후잉유빈번전간발작,재차수술절제종류주위치간조후전간득도완전공제.결론 DNT응당안조피질발육장애래처리,제절제종류외,적겁처리종류외치간조가획득교가적전간공제결과.
Objective To investigate the management of drug-resistant epilepsy in patients with dysembryoplastic neuroepithelial tumor (DNT). Methods Surgical experiences of 14 patients with DNT in our hospital were retrospectively reviewed. According to the EeoG during the operation and preoperative evaluation, the epileptic foci were managed when the tumor resection was performed. Results The tumors were cut off completely in all the patients; no radiotherapy or chemotherapy was performed after the operation; no recurrence or metastasis of the tumor was found. Engel Ⅰ outcome (seizure-free) was noted in 11 patients and Engel Ⅱ outcome (rare seizure) was noted in 2; frequent seizure was found in 1 after the first operation and seizure-free was achieved after the resection of epileptic foci around the tumor. Conclusion The DNT should be treated as having malformation in the cortical dysplasia and management of epileptic foci around the tumor shows favorable results in the controlling of epilepsy.