CAJ | 학술논문

目的了解临床初诊为视神经炎(ON)儿童患者的病因分布和临床特点.方法收集158例初诊ON的儿童患者详细的眼科和神经内科检查及实验室、影像学检查资料,参照国际认可的标准重新诊断,并与成人ON病因进行比较.结果 104例初诊为ON的儿童患者最后诊断符合ON,占65.8%.其中,80例为特发性脱髓鞘性ON,占76.9%;感染性ON和炎性视神经病各3例,18例病因未明.另54例不符合ON诊断,其中,以Leber遗传性视神经病、非器质性视力下降等较常见.结论初诊为ON的儿童患者病因分布与成人类似,以特发性脱髓鞘性ON最为常见.Leber遗传性视神经病和非器质性视力下降是儿童患者中最常见的与ON混淆的疾病.
목적 료해림상초진위시신경염(ON)인동환자적병인분포화림상특점.방법 수집158례초진ON적인동환자상세적안과화신경내과검사급실험실、영상학검사자료,삼조국제인가적표준중신진단,병여성인ON병인진행비교.결과 104례초진위ON적인동환자최후진단부합ON,점65.8%.기중,80례위특발성탈수초성ON,점76.9%;감염성ON화염성시신경병각3례,18례병인미명.령54례불부합ON진단,기중,이Leber유전성시신경병、비기질성시력하강등교상견.결론 초진위ON적인동환자병인분포여성인유사,이특발성탈수초성ON최위상견.Leber유전성시신경병화비기질성시력하강시인동환자중최상견적여ON혼효적질병.
Objective To explore underlying causes of presumptive optic neuritis(ON)in children.Methods Retrospective study of continuous cases with presumed diagnosis of optic neuritis in childhood.Results 104 cases(65.8%)met ON criteria in this cohort of children,among which 80 cases(76.9%)were considered as idiopathic demyelinating optic neuritis(IDON).Infectious optic neuritis and inflammatory optic neuropathy were found on 3 cases respectively.The cause of 18 cases remains unknown.Leber hereditary optic neuropathy and non-organic visual acuity loss account most of the 54cases misdiagnosed as optic neuritis.Conclusions As in adult patients,idiopathic demyelinating optic neuritis is the most common pathogeny of optic neuritis in children,while infectious events were more common in children.Leber hereditary optic neuropathy and non-organic visual acuity loss were the most common disease confused with optic neuritis in childhood.Some rare disease in childhood which can causeoptic nerve lesion should also be considered.