军事医学科学院院刊
軍事醫學科學院院刊
군사의학과학원원간
BULLETIN OF THE ACADEMY OF MILITARY MEDICAL SCIENCES
2010年
1期
80-83
,共4页
刘一沉%任长虹%王航雁%张成岗
劉一沉%任長虹%王航雁%張成崗
류일침%임장홍%왕항안%장성강
不均一性核糖核蛋白%神经细胞%神经胶质细胞%中枢神经系统%神经系统疾病
不均一性覈糖覈蛋白%神經細胞%神經膠質細胞%中樞神經繫統%神經繫統疾病
불균일성핵당핵단백%신경세포%신경효질세포%중추신경계통%신경계통질병
heterogeneous nuclear ribonucleoprotein%neuron%glial cell%central nervous system%nervous system disease
不均一性核糖核蛋白(heterogeneous nuclear ribonucleoprotein, hnRNP)是一类可参与mRNA前体剪接、mRNA转运和降解等多种功能的RNA结合蛋白.目前发现hnRNP家族蛋白也参与了神经细胞、神经胶质细胞的生长调控过程,并且与多种中枢神经系统疾病的发生发展密切相关.该文对hnRNP的结构、功能及其在中枢神经系统中的作用进行综述,旨在为理解神经系统疾病的分子机制提供新线索.
不均一性覈糖覈蛋白(heterogeneous nuclear ribonucleoprotein, hnRNP)是一類可參與mRNA前體剪接、mRNA轉運和降解等多種功能的RNA結閤蛋白.目前髮現hnRNP傢族蛋白也參與瞭神經細胞、神經膠質細胞的生長調控過程,併且與多種中樞神經繫統疾病的髮生髮展密切相關.該文對hnRNP的結構、功能及其在中樞神經繫統中的作用進行綜述,旨在為理解神經繫統疾病的分子機製提供新線索.
불균일성핵당핵단백(heterogeneous nuclear ribonucleoprotein, hnRNP)시일류가삼여mRNA전체전접、mRNA전운화강해등다충공능적RNA결합단백.목전발현hnRNP가족단백야삼여료신경세포、신경효질세포적생장조공과정,병차여다충중추신경계통질병적발생발전밀절상관.해문대hnRNP적결구、공능급기재중추신경계통중적작용진행종술,지재위리해신경계통질병적분자궤제제공신선색.
Heterogeneous nuclear ribonulcleoprotein(hnRNP)plays a variety of roles in pre-mRNA splicing, nuclear export of mRNA and turnover. It is reported that hnRNP not only takes part in regulating the development of neuron and glial cells, but is closely related to various central nervous system diseases. This paper reviewed the structure, function and the role of hnRNP in the central nervous system in order to provide new insight into the molecule mechanism of nervous system diseases.
