CAJ | 학술논문

目的：分析探讨原发性中枢神经系统淋巴瘤（primary central nervous system lymphoma,PCNSL）的临床特征、磁共振表现、治疗方法及预后。方法：回顾性分析我院2005年至2010年收治的18例PCNSL患者的临床资料。结果：临床表现复杂多样,以高颅压、癫痫发作以及局灶性神经功能缺失等常见;磁共振表现多为低T1、高T2信号影,增强常呈明显均匀强化,常发生于幕上,可单发或多发,极少发生囊变、出血或钙化;单纯手术3例,术后全脑放疗3例,联合化疗、放疗12例,联合治疗的患者生存期明显延长。结论：PCNSL的临床特征及磁共振表现均缺乏特异性,术前难以确诊,单纯手术治疗效果较差,联合化疗、放疗能明显延长患者的生存期。
목적：분석탐토원발성중추신경계통림파류（primary central nervous system lymphoma,PCNSL）적림상특정、자공진표현、치료방법급예후。방법：회고성분석아원2005년지2010년수치적18례PCNSL환자적림상자료。결과：림상표현복잡다양,이고로압、전간발작이급국조성신경공능결실등상견;자공진표현다위저T1、고T2신호영,증강상정명현균균강화,상발생우막상,가단발혹다발,겁소발생낭변、출혈혹개화;단순수술3례,술후전뇌방료3례,연합화료、방료12례,연합치료적환자생존기명현연장。결론：PCNSL적림상특정급자공진표현균결핍특이성,술전난이학진,단순수술치료효과교차,연합화료、방료능명현연장환자적생존기。
Objective：To review the clinical features,MRI manifestation,treatment and prognosis of primary central nervous system lymphoma（PCNSL）.Methods：Clinical datas of 18 cases of PCNSL admitted to the First Affiliated Hospital of Medical University of Chongqing from 2005 to 2010 were analysed retrospectively.Results：PCNSL showed variable clinical features,among which the symptoms of elevated intracranial pressure,neurologic dysfunctions and seizures were most common;MRI indicated hypo-signal in TlWI and hyper-signal in T2WI.Enhanced scanning showed the lesion was contrasted evenly and obviously with rarely cystic degeneration,hemorrhage and calcification.It might be solitary or mutiple and often occured in the supratentorial space;3 patients only accepted resection and 3 accepted whole brain radiotherapy after resection.The last 12 patients were given combined therapy including resection,chemotherapy and radiotherapy.The survival of patients who accepted combined therapy was significantly longer than that of those who accepted surgery alone or postoperative radiotherapy.Conclusion： It was difficult to preoperative diagnose since PCNSL showed no specificity in clinical features and MRI manifestation.The effect of treatment was poor with surgery alone,however the survival of patients extended significantly after combined with chemotherapy and radiotherapy..