中华创伤杂志英文版
中華創傷雜誌英文版
중화창상잡지영문판
CHINESE JOURNAL OF TRAUMATOLOGY (ENGLISH EDITION)
2005年
1期
54-56
,共3页
王维平%任海军%池京洋%徐福林%全勇
王維平%任海軍%池京洋%徐福林%全勇
왕유평%임해군%지경양%서복림%전용
Brain injury%Intracranial pressure%Hypothermia
Objective: To study the effects of mild hypothermia therapy on severe brain-injured patients whose intracranial pressure (ICP) could be maintained below 25 mm Hg.Methods: Forty severe brain-injured patients with ICP below 25 mm Hg were divided randomly into one treatment group (n=20, mild hypothermia therapy) and one control group (n=20, normothermia therapy) to observe the changes of the concentration of excitatory amino acids (glutamate and glycine) and cytokines (interleukin-1β and interleukin-6). Results: There were no significant differences in the daily changes of the concentration of excitatory amino acid and cytokines between two groups. The outcome of two groups had no significant differences. Conclusions: Mild hypothermia has no additional beneficial effects on severe brain-injured patients compared with normothermia therapy if ICP can be maintained below 25 mm Hg by using conventional therapy.
