CAJ | 학술논문

具有两个formin同源结构域(FH1和FH2)的成蛋白(Formins)家族,是维持细胞骨架肌动蛋白的重要调节因子.Diaphanous相关成蛋白家族因具有GTPase结合结构域(GBD)和Diaphanous 自调控结构域(DAD)而被划分为成蛋白家族的一个亚类,该亚家族对细胞黏附、运动、胞质分裂、形态发生、细胞极性的形成、血清反应因子的激活等起重要的调控作用,参与Rho/Rock细胞信号转导通路,并通过调节肌动蛋白细胞骨架重组,促进肿瘤细胞的迁移、侵袭和转移.对Diaphanous相关成蛋白亚家族的深入研究,有助于进一步揭示肿瘤细胞的侵袭和转移机制,并可能为临床提供新的治疗靶点.
구유량개formin동원결구역(FH1화FH2)적성단백(Formins)가족,시유지세포골가기동단백적중요조절인자.Diaphanous상관성단백가족인구유GTPase결합결구역(GBD)화Diaphanous 자조공결구역(DAD)이피화분위성단백가족적일개아류,해아가족대세포점부、운동、포질분렬、형태발생、세포겁성적형성、혈청반응인자적격활등기중요적조공작용,삼여Rho/Rock세포신호전도통로,병통과조절기동단백세포골가중조,촉진종류세포적천이、침습화전이.대Diaphanous상관성단백아가족적심입연구,유조우진일보게시종류세포적침습화전이궤제,병가능위림상제공신적치료파점.
Forming are regulator of actin cytoskeleton. They are characterized with two formin homology domains. Diaphanous-related formin (DRF) is isolated as a subfamily because they have two specific domains such as CBD(GTPase binding domain) and DAD(Diaphanous-autoregulatory domain). DRF is required for a growing number of biological progresses, such as cell adhesion and motility,cytokinesis, morphogenesis, cell polarity and the transcriptional activation of serum response factor. They are closely invovled in cell signal transduction of Rho/Rock, so they play an important role in actin cytoskeleton rearrangements and the process of neoplasm invasion and matastasis. DRF should be studied further, for it will be helpful for deep revealing the mechanism of neoplasm invasion and matastasis, and may be an important basis of potential targets for clinic practice.