CAJ | 학술논문

DC-SIGN和DC-SIGNR是两种表达于DC表面的蛋白,被认为是许多病原微生物的黏附受体,参与很多病原微生物的感染.DC-SIGN和DC-SIGNR(DC-SIGN/DC-SIGNR)的多态性或许影响病原微生物的感染过程和结果.此文对DC-SIGN/DC-SIGNR的结构功能以及与HIV、HCV感染、肺结核、登革热的关系进行了综述.
DC-SIGN화DC-SIGNR시량충표체우DC표면적단백,피인위시허다병원미생물적점부수체,삼여흔다병원미생물적감염.DC-SIGN화DC-SIGNR(DC-SIGN/DC-SIGNR)적다태성혹허영향병원미생물적감염과정화결과.차문대DC-SIGN/DC-SIGNR적결구공능이급여HIV、HCV감염、폐결핵、등혁열적관계진행료종술.
DC-SIGN and DC-SIGNR are two surface proteins on dendritic cells with complex stmction, and are regarded as attachment receptors of many pathogens, DC-SIGN/DC-SIGNR participate in pathogen infection.Polymorphisms of DC-SIGN/DC-SIGNR probably influence the procedure and outcome of pathogen infection. In this article, the structure and function of DC-SIGN/DC-SIGNR are discussed as well as the relation between the DC-SIGN/DC-SIGNR and pathogens such as HIV, HCV infection, pulmonary tuberculosis, dengue fever.