CAJ | 학술논문

目的探讨手术去势与晚期前列腺癌患者胰岛素抵抗的相关性.方法 67例晚期前列腺癌患者根据体重指数(BMI)分为肥胖组(30例)和非肥胖组(37例),两组患者均采用手术去势的治疗方法;并在治疗前、治疗后6个月、治疗后12个月分别测定患者空腹血糖(FBC)、空腹胰岛素,并计算胰岛素抵抗指数(IRI).结果肥胖组空腹胰岛素在治疗后6个月[(23.21±5.78)mU/L]及12个月[(24.34±5.37)mU/L]比治疗前[(20.01±4.82)mU/L]均升高.非肥胖组空腹胰岛素在治疗后12个月[(22.19±6.14)mU/L]比治疗前[(17.36±6.01)mU/L]升高.肥胖组IRI在治疗后6个月(2.94±0.79)及12个月(3.10±0.73)比治疗前(2.53±0.64)均升高.非肥胖组IRI在治疗后12个月(2.79±0.75)比治疗前(2.17±0.73)升高,上述差异均有统计学意义.结论手术去势会促使晚期前列腺癌患者胰岛素抵抗的发生,并会进一步导致心血管并发症和2型糖尿病的发生.
목적 탐토수술거세여만기전렬선암환자이도소저항적상관성.방법 67례만기전렬선암환자근거체중지수(BMI)분위비반조(30례)화비비반조(37례),량조환자균채용수술거세적치료방법;병재치료전、치료후6개월、치료후12개월분별측정환자공복혈당(FBC)、공복이도소,병계산이도소저항지수(IRI).결과 비반조공복이도소재치료후6개월[(23.21±5.78)mU/L]급12개월[(24.34±5.37)mU/L]비치료전[(20.01±4.82)mU/L]균승고.비비반조공복이도소재치료후12개월[(22.19±6.14)mU/L]비치료전[(17.36±6.01)mU/L]승고.비반조IRI재치료후6개월(2.94±0.79)급12개월(3.10±0.73)비치료전(2.53±0.64)균승고.비비반조IRI재치료후12개월(2.79±0.75)비치료전(2.17±0.73)승고,상술차이균유통계학의의.결론 수술거세회촉사만기전렬선암환자이도소저항적발생,병회진일보도치심혈관병발증화2형당뇨병적발생.
Objective To investigate the role of insulin resistance in patients with prostate cancer who received surgical castration. Methods Sixty-seven patients with advanced prostate cancer who received with surgical castration were divided into obesity group [30 cases, BMI (26.85±1.22) kg/m2] and non-obesity group[37 cases, BMI(22.72±1.28) kg/m2]. The fasting blood glucose (FBG) and the fasting serum insulin, while evaluated the insulin resistance index(IRI) were determined before treatment, 6 months after treatment and 12 months after treatment. Results The levels of fasting serum insulin were significantly higher 6 months[(23.21±5.78 )mU/L] and 12 months [(24.34±5.37) mU/L] after treatment than that be-fore treatment[(20.01±4.82) mU/L] in obesity group, but 12 months after treatment [(22.19±6.14) mU/L ]was higher than that before treatment [(17.36±6.01) mU/L] in non-obesity group (P<0.01). The IRI were significantly higher 6 months (2.94±0.79) and 12 months (3.10±0.73) after treatment than that be-fore treatment (2.53±0.64) in obesity group, but 12 months after treatment (2.79±0.75) was higher than that before treatmeat(2.17±0.73) in non-obesity group(P<0.01). Conclusion The current data suggests that the patients with prostate cancer who received surgical castration is at risk for developing insulin resistance, thus leading to increasing risk of cardiovascular disease and type 2 diabetes mellitus.