中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2010年
3期
241-242
,共2页
张建民%闫永建%林立%聂继池
張建民%閆永建%林立%聶繼池
장건민%염영건%림립%섭계지
溴氰菊酯%亚慢性染毒%学习%记忆
溴氰菊酯%亞慢性染毒%學習%記憶
추청국지%아만성염독%학습%기억
Deltamethrin%Subchronie poisoning%Learning%Memory
目的 探讨溴氰菊酯亚慢性染毒对小鼠学习记忆功能的影响及意义.方法 按确定的溴氰菊酯高、中、低染毒剂量,对小鼠进行灌胃染毒,染毒时间为30d.对染毒后小鼠进行Y型臂迷宫试验和跳台试验.结果 Y型迷宫试验中,高剂量染毒组、中剂量染毒组、低剂量染毒组的总电击时间分别为(39.10±16.21)s、(34.54±12.19)s、(28.99±11.72)8,总训练次数分别为(70.35±28.07)次、(66.24±27.10)次、(60.58±23.49)次,错误反应次数分别为(34.89±14.64)次、(31.31±11.29)次、(28.62±9.28)次.与对照组比较,高剂量染毒组总电击时间延长,总训练次数、错误反应次数增加,正确反应率下降,均差异有显著性(P＜0.05,P＜0.01),中剂量染毒组除总训练次数外,其余各指标也差异有显著性(P＜0.05,P＜0.01).与对照组比较,高剂鼍染毒组、中剂量染毒组染毒后跳台试验错误潜伏期显著缩短、错误次数显著增多、电击时间显著延长,均差异有显著性(P＜0.05,P＜0.01),低剂量染毒组染毒后错误次数显著增多,差异具有显著性(P＜0.05).结论 溴氰菊酯亚慢性染毒可降f氐小鼠的学习记忆功能.
目的 探討溴氰菊酯亞慢性染毒對小鼠學習記憶功能的影響及意義.方法 按確定的溴氰菊酯高、中、低染毒劑量,對小鼠進行灌胃染毒,染毒時間為30d.對染毒後小鼠進行Y型臂迷宮試驗和跳檯試驗.結果 Y型迷宮試驗中,高劑量染毒組、中劑量染毒組、低劑量染毒組的總電擊時間分彆為(39.10±16.21)s、(34.54±12.19)s、(28.99±11.72)8,總訓練次數分彆為(70.35±28.07)次、(66.24±27.10)次、(60.58±23.49)次,錯誤反應次數分彆為(34.89±14.64)次、(31.31±11.29)次、(28.62±9.28)次.與對照組比較,高劑量染毒組總電擊時間延長,總訓練次數、錯誤反應次數增加,正確反應率下降,均差異有顯著性(P＜0.05,P＜0.01),中劑量染毒組除總訓練次數外,其餘各指標也差異有顯著性(P＜0.05,P＜0.01).與對照組比較,高劑鼉染毒組、中劑量染毒組染毒後跳檯試驗錯誤潛伏期顯著縮短、錯誤次數顯著增多、電擊時間顯著延長,均差異有顯著性(P＜0.05,P＜0.01),低劑量染毒組染毒後錯誤次數顯著增多,差異具有顯著性(P＜0.05).結論 溴氰菊酯亞慢性染毒可降f氐小鼠的學習記憶功能.
목적 탐토추청국지아만성염독대소서학습기억공능적영향급의의.방법 안학정적추청국지고、중、저염독제량,대소서진행관위염독,염독시간위30d.대염독후소서진행Y형비미궁시험화도태시험.결과 Y형미궁시험중,고제량염독조、중제량염독조、저제량염독조적총전격시간분별위(39.10±16.21)s、(34.54±12.19)s、(28.99±11.72)8,총훈련차수분별위(70.35±28.07)차、(66.24±27.10)차、(60.58±23.49)차,착오반응차수분별위(34.89±14.64)차、(31.31±11.29)차、(28.62±9.28)차.여대조조비교,고제량염독조총전격시간연장,총훈련차수、착오반응차수증가,정학반응솔하강,균차이유현저성(P＜0.05,P＜0.01),중제량염독조제총훈련차수외,기여각지표야차이유현저성(P＜0.05,P＜0.01).여대조조비교,고제타염독조、중제량염독조염독후도태시험착오잠복기현저축단、착오차수현저증다、전격시간현저연장,균차이유현저성(P＜0.05,P＜0.01),저제량염독조염독후착오차수현저증다,차이구유현저성(P＜0.05).결론 추청국지아만성염독가강f저소서적학습기억공능.
Objective To study the learning and memory functions of mice with subchronic poisoning by deltamethrin.Methods Mice were randomly divided into high-dose poisoning group,middle-dose poisoning group and low-dose poisoning group with different poisoning doses of deltamethrin by mouth for 30 d.After poisoning,the Y model maze test and diving tower test were carried out in each group.Results In the learning test of Y model maze test,the total electric shock period were(39.10±16.21)s,(34.54±12.19)s and(28.99±11.72)s,the total training times were(70.35±28.07)times,(66.24±27.10)times and(60.58±23.49)times,and the error reaction times were(34.89±14.64)times,(31.31±11.29)times and(28.62±9.28)times,respectively in high-dose poisoning group,middle-dose poisoning group and low-dose poisoning group.Compared with control group,the total electric shock period,the total training times,the error reaction times of and the rate of right reaction in high-dose poisoning group and middle-dose poisoning group(except for the index of the total training times in middle-dose poisoning group)increased significantly(P＜0.01,P＜0.05)In the diving tower test,compared with control group,the error latent period shortened and the error times and total short electric shock periods increased significantly in high-dose poisoning group and middle-dose poisoning group(P＜0.01,P＜0.05).Conclusion Subchronic poisoning by dehamethrin could result in decrease of the learning and memory functions of mice.
