实用临床医学
實用臨床醫學
실용림상의학
Practical Clinical Medicine
2009年
5期
8-10
,共3页
咪唑安定%怀孕大鼠%子代%学习记忆%尾静脉%动物,实验%大鼠
咪唑安定%懷孕大鼠%子代%學習記憶%尾靜脈%動物,實驗%大鼠
미서안정%부잉대서%자대%학습기억%미정맥%동물,실험%대서
midazolam%pregnant rats%offspring%learning and memory%tail vein%animals,laboratory%rats
目的 研究怀孕大鼠接受咪唑安定对其子代学习记忆功能的影响.方法 怀孕SD大鼠30只,随机分为咪唑安定组(M组)与对照组(C组),各15只,M组经尾静脉给予咪唑安定并维持2 h,C组单次尾静脉给予等诱导剂量的生理盐水;然后分别对其所产子鼠按20日龄、30日龄分组,应用Morris水迷宫实验测试子鼠空间学习记忆功能.结果 20日龄、30日龄M组子鼠与C组子鼠的逃避潜伏期组间比较均无显著性差异.结论 怀孕大鼠接受咪唑安定对其子代学习记忆功能无明显影响.
目的 研究懷孕大鼠接受咪唑安定對其子代學習記憶功能的影響.方法 懷孕SD大鼠30隻,隨機分為咪唑安定組(M組)與對照組(C組),各15隻,M組經尾靜脈給予咪唑安定併維持2 h,C組單次尾靜脈給予等誘導劑量的生理鹽水;然後分彆對其所產子鼠按20日齡、30日齡分組,應用Morris水迷宮實驗測試子鼠空間學習記憶功能.結果 20日齡、30日齡M組子鼠與C組子鼠的逃避潛伏期組間比較均無顯著性差異.結論 懷孕大鼠接受咪唑安定對其子代學習記憶功能無明顯影響.
목적 연구부잉대서접수미서안정대기자대학습기억공능적영향.방법 부잉SD대서30지,수궤분위미서안정조(M조)여대조조(C조),각15지,M조경미정맥급여미서안정병유지2 h,C조단차미정맥급여등유도제량적생리염수;연후분별대기소산자서안20일령、30일령분조,응용Morris수미궁실험측시자서공간학습기억공능.결과 20일령、30일령M조자서여C조자서적도피잠복기조간비교균무현저성차이.결론 부잉대서접수미서안정대기자대학습기억공능무명현영향.
Objective To study the effects of Midazolam during pregnancy on the learning and memory function of rat offspring.Methods Thirty pregnant SD rats were randomly divided into midazolam group(group M)and control group(group C),with fifteen rats in each group.The rats in group M received midazolam via tail vein for 2 hours,and the rats in group C received the same volume of physiological saline solution only.The learning and memory functions of the offspring were tested by Morris water maze test at postnatal days 20 and 30,respectively.Results There was no significant difference in escape latency of the offspring between group M and group C.Conclusion Midazolam had no significant effect on the learning and memory function of rat offspring during pregnancy.
