CAJ | 학술논문

目的研究复方尿囊素片对阿司匹林所致大鼠急性胃黏膜损伤的预防保护作用.方法 60只健康雄性Wistar大鼠随机分成5组:阿司匹林损伤组(Ⅰ组)、空白对照组(Ⅱ组)、硫糖铝保护组(Ⅲ组)、氢氧化铝保护组(Ⅳ组)、复方尿囊素保护组(Ⅴ组).保护组分别用硫糖铝、氢氧化铝及复方尿囊素片提前给大鼠灌胃,其后用阿司匹林灌胃致急性胃黏膜损伤,然后分别测定各组大鼠的黏膜溃疡指数(UI),并在显微镜及电镜下观察胃黏膜组织学改变,分别测定各组胃黏膜损伤积分(EDS),以评价损伤程度及药物的预防保护效果.结果 Ⅰ组、Ⅱ组、Ⅲ组、Ⅳ组、Ⅴ组的溃疡指数分别为42.13±6.22、3.13±1.46、8.63±3.48、18.00±6.16、8.00±3.17;黏膜损伤积分分别为3.67±0.49、1.25±0.45、1.41±0.51、2.42±0.79、1.50±0.52.各保护组溃疡指数、损伤积分明显低于阿司匹林损伤组,复方尿囊素组的溃疡指数、损伤积分均明显低于氢氧化铝组(P＜0.01),略低于硫糖铝保护组,但差异无统计学意义(P＞0.05).结论复方尿囊素片对阿司匹林所致大鼠急性胃黏膜损伤有明显的预防保护作用.
목적 연구복방뇨낭소편대아사필림소치대서급성위점막손상적예방보호작용.방법 60지건강웅성Wistar대서수궤분성5조:아사필림손상조(Ⅰ조)、공백대조조(Ⅱ조)、류당려보호조(Ⅲ조)、경양화려보호조(Ⅳ조)、복방뇨낭소보호조(Ⅴ조).보호조분별용류당려、경양화려급복방뇨낭소편제전급대서관위,기후용아사필림관위치급성위점막손상,연후분별측정각조대서적점막궤양지수(UI),병재현미경급전경하관찰위점막조직학개변,분별측정각조위점막손상적분(EDS),이평개손상정도급약물적예방보호효과.결과 Ⅰ조、Ⅱ조、Ⅲ조、Ⅳ조、Ⅴ조적궤양지수분별위42.13±6.22、3.13±1.46、8.63±3.48、18.00±6.16、8.00±3.17;점막손상적분분별위3.67±0.49、1.25±0.45、1.41±0.51、2.42±0.79、1.50±0.52.각보호조궤양지수、손상적분명현저우아사필림손상조,복방뇨낭소조적궤양지수、손상적분균명현저우경양화려조(P＜0.01),략저우류당려보호조,단차이무통계학의의(P＞0.05).결론 복방뇨낭소편대아사필림소치대서급성위점막손상유명현적예방보호작용.
Objective To study the protective effects of aldioxa tablets on aspirin-induced gastric mucosal lesions in rat model. Methods Sixty healthy male Wistar rats were randomly divided into five groups: Ⅰ (injury group), Ⅱ (control group), Ⅲ (sucralfate protective group), Ⅳ (aluminium hydroxide protective group), and Ⅴ (aldioxa protective group). The three protective groups were treated with sucralfate, aluminium hydroxide and aldioxa tablets respectively before gastric mucosal injury was induced. Then the ulcer index (UI), epithelial damage scoring (EDS) were measured, and the pathological changes on histological sections and ultrastructural sections of gastric mucosa were assessed under microscope or electron microscope. Results The data of group Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅴ obtained were as follow: ulcer index: 42.13±6.22, 3.13±1.46, 8.63±3.48, 18.00±6.16, 8.00±3.17, respectively; epithelial damage scoring: 3.67±0.49, 1.25±0.45, 1.41±0.51, 2.42±0.79, 1.50±0.52, respectively. In comparison with injury group, the ulcer index and epithelial damage scoring of gastric mucosa in aldioxa protective group were significantly decreased. Conclusions The results revealed that aldioxa tablets had a significant protection effect on rats with acute gastric mucosal injury induced by aspirin.