中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
2期
162-163
,共2页
宫颈癌%环氧合酶2%免疫组织化学
宮頸癌%環氧閤酶2%免疫組織化學
궁경암%배양합매2%면역조직화학
Cervical cancer%Cyclooxygenase-2%Immunohistochemistry
目的 探讨环氧合酶2(COX-2)在宫颈上皮内瘤样(CIN)病变及宫颈癌组织中的表达及临床意义.方法 采用免疫组织化学方法,检测COX-2在45例宫颈癌、25例CIN和20例正常宫颈组织中的表达水平.结果 COX-2在正常宫颈组织中无表达;在CIN中的表达率为44.0%(11/25),在宫颈癌中的表达率为82.2%(37/45),三者比较,差异有统计学意义(P<0.01).G_1级宫颈癌COX-2的表达明显高于G_2、C_3级宫颈癌(P<0.05),有淋巴结转移癌COX-2的表达明显高于无淋巴结转移癌(P<0.05);COX-2的表达与肿瘤大小、组织学类型及FIGO分期无关(P>0.05).结论 COX-2的过表达可能参与了宫颈癌的发生和发展.
目的 探討環氧閤酶2(COX-2)在宮頸上皮內瘤樣(CIN)病變及宮頸癌組織中的錶達及臨床意義.方法 採用免疫組織化學方法,檢測COX-2在45例宮頸癌、25例CIN和20例正常宮頸組織中的錶達水平.結果 COX-2在正常宮頸組織中無錶達;在CIN中的錶達率為44.0%(11/25),在宮頸癌中的錶達率為82.2%(37/45),三者比較,差異有統計學意義(P<0.01).G_1級宮頸癌COX-2的錶達明顯高于G_2、C_3級宮頸癌(P<0.05),有淋巴結轉移癌COX-2的錶達明顯高于無淋巴結轉移癌(P<0.05);COX-2的錶達與腫瘤大小、組織學類型及FIGO分期無關(P>0.05).結論 COX-2的過錶達可能參與瞭宮頸癌的髮生和髮展.
목적 탐토배양합매2(COX-2)재궁경상피내류양(CIN)병변급궁경암조직중적표체급림상의의.방법 채용면역조직화학방법,검측COX-2재45례궁경암、25례CIN화20례정상궁경조직중적표체수평.결과 COX-2재정상궁경조직중무표체;재CIN중적표체솔위44.0%(11/25),재궁경암중적표체솔위82.2%(37/45),삼자비교,차이유통계학의의(P<0.01).G_1급궁경암COX-2적표체명현고우G_2、C_3급궁경암(P<0.05),유림파결전이암COX-2적표체명현고우무림파결전이암(P<0.05);COX-2적표체여종류대소、조직학류형급FIGO분기무관(P>0.05).결론 COX-2적과표체가능삼여료궁경암적발생화발전.
Objective To study the expression and clinical significance of cyclooxygenase(COX)-2 in cer-vical intraepithelial neoplasia(CIN) and cervical cancer. Methods The expression of COX-2 in the cervical cancer (n=45), CIN (n=25) and normal cervical tissue (n=20) were detected by immunohistochemistry method. Results The positive rate of COX-2 in cervical cancer were 82.2% (37/45), 44.0% (11/25) in CIN and no expression in normal cervical tissue. Showing no significant difference among 3 groups(P <0.01). The positive rate of COX-2 in G_1 -class were significantly higher than that in G_2, G_3-class (P < 0.05). The positive rate of COX-2 in existing lymph node metastasis was significantly higher than that in non-existing lymph node metastasis(P < 0.05) but showed no significant relation with the tumor size, type of histological and stage of FIGO (P > 0.05). Conclusion The over-expression of COX-2 may be involved in occurrence and development of cervical cancer.
