CAJ | 학술논문

目的探讨多奈哌齐联合康复治疗对早期脑卒中偏瘫患者运动功能及认知的影响.方法 40例发病3～14 d的脑卒中偏瘫患者按照由神经内科转入康复科先后顺序分为两组,单号18例为对照组给予常规康复训练;双号22例为研究组在进行常规康复训练的同时,给予多奈哌齐5 mg,1次/d口服,分别在转入康复科时和1个月、2个月后采用简式Fugl-Meyer运动量表(FMA)、Barthel指数评分法及简易智能精神状态检查量表(MMSE)评定疗效.结果早期康复后患者的运动功能和日常生活能力及认知均明显提高,差别有统计学意义(均P<0.05),而研究组较对照组的FMA、Barthel指数及MMSE评分改善差异有统计学意义(均P<0.01).研究组治疗前后生命体征、血常规、肝功能、血脂、血糖、心电图等指标治疗前后均无明显变化(P0.05)、无严重不良反应.结论早期脑卒中偏瘫患者多奈哌齐联合康复治疗可明显改善患者的认知、运动及日常生活能力,且安全性好.
목적 탐토다내고제연합강복치료대조기뇌졸중편탄환자운동공능급인지적영향.방법 40례발병3～14 d적뇌졸중편탄환자안조유신경내과전입강복과선후순서분위량조,단호18례위대조조급여상규강복훈련;쌍호22례위연구조재진행상규강복훈련적동시,급여다내고제5 mg,1차/d구복,분별재전입강복과시화1개월、2개월후채용간식Fugl-Meyer운동량표(FMA)、Barthel지수평분법급간역지능정신상태검사량표(MMSE)평정료효.결과 조기강복후환자적운동공능화일상생활능력급인지균명현제고,차별유통계학의의(균P<0.05),이연구조교대조조적FMA、Barthel지수급MMSE평분개선차이유통계학의의(균P<0.01).연구조치료전후생명체정、혈상규、간공능、혈지、혈당、심전도등지표치료전후균무명현변화(P0.05)、무엄중불량반응.결론 조기뇌졸중편탄환자다내고제연합강복치료가명현개선환자적인지、운동급일상생활능력,차안전성호.
Objective To study the effect of early Donepezil and rehabilitation on motor function and eognize in stroke hemiplegia patients. Methods Forty stroke patients were enrolled into two groups stochastically, 18 collator received general training and 22 curets received rehabilitation training and taken Donepezil 5 mg/d. The FMA, Barthel and MMSE index were administered to evaluate curative effect during first visit to a doctor and following 1 and 2 months. Results After rehabilitation the motor function, daily life abilities and cognize were improved(P <0.01 ). The treatment group was superior to the control group, showing significant differences before and after treatment(P < 0. 01 ). Conclusion Early Donepezil and rehabilitation can improve the cognize, motor function and ADL of stroke hemiplegia patients.