CAJ | 학술논문

目的了解我国老年人群慢性肾脏疾病(CKD)的患病率及其影响因素.方法对2004年1月至2007年1月长期在北京医院老年病房进行健康查体及疾病治疗、病历资料完整的老年人进行回顾性调查.分别记录受检者年龄、身高、体质量、血压、血尿、蛋白尿、血红蛋白、血肌酐、血尿素、血脂、血尿酸、乙肝表面抗原、影像学检查结果以及既往诊断疾病情况,采用公式法估算肾小球滤过率,并对影响蛋白尿及CKD的危险因素进行二分类Logistic回归分析.结果 1082例老年人中,蛋白尿检出率为4.9%,肾功能下降为47.2%,CKD检出率为48.4%;多因素Logistic回归分析表明,糖尿病(OR=2.257)和镜下血尿(OR=5.324)是老年人发生蛋白尿的危险因素(P<0.05),高血压(OR=1.459)、冠心病(OR=3.290)、慢性阻塞性肺病(OR=2.094)、恶性肿瘤(OR=2.072)、高尿酸血症(OR=1.928)、贫血(OR=8.122)、血尿(OR=1.604)是发生CKD的危险因素(P<0.05).结论初步估计我国特殊老年人群的CKD患病率为48.4%,相关危险因素有糖尿病、高血压、高尿酸血症、贫血等,与发达国家水平相似.
목적 료해아국노년인군만성신장질병(CKD)적환병솔급기영향인소.방법 대2004년1월지2007년1월장기재북경의원노년병방진행건강사체급질병치료、병력자료완정적노년인진행회고성조사.분별기록수검자년령、신고、체질량、혈압、혈뇨、단백뇨、혈홍단백、혈기항、혈뇨소、혈지、혈뇨산、을간표면항원、영상학검사결과 이급기왕진단질병정황,채용공식법고산신소구려과솔,병대영향단백뇨급CKD적위험인소진행이분류Logistic회귀분석.결과 1082례노년인중,단백뇨검출솔위4.9%,신공능하강위47.2%,CKD검출솔위48.4%;다인소Logistic회귀분석표명,당뇨병(OR=2.257)화경하혈뇨(OR=5.324)시노년인발생단백뇨적위험인소(P<0.05),고혈압(OR=1.459)、관심병(OR=3.290)、만성조새성폐병(OR=2.094)、악성종류(OR=2.072)、고뇨산혈증(OR=1.928)、빈혈(OR=8.122)、혈뇨(OR=1.604)시발생CKD적위험인소(P<0.05).결론 초보고계아국특수노년인군적CKD환병솔위48.4%,상관위험인소유당뇨병、고혈압、고뇨산혈증、빈혈등,여발체국가수평상사.
Objective To investigate the prevalence of chronic kidney disease (CKD) and its risk factors in Chinese elderly persons.Methods All of the people who underwent physical examination and treatment in the geriatric department of Beijing Hospital during January 2004 to January 2007 were included in the study.Age, body height, body mass index and blood pressure were recorded.Bloody urine was ascertained by phase-contrast microscope, and urine protein was measured by dipstick test.The hemoglobulin, serum eretinine, blood urea nitrogen, blood lipid and serum uric acid were measured by autobiochemical analyzer.HbsAg was checked by enzyme-linked immunosorbent assay (ELISA).Glomerular filtration rate (GFR) was estimated by Crockeroft-Gauh equation and abbreviated MDRD equation.Binary logistic regression analysis was used to test the risk factors for proteinuria and CKD.Results The prevalence of proteinuria was 4.9% in 1082 elderly persons.And 47.23% of the elderly suffered from decreased renal function.The morbidity of CKD was 48.43%.Binary logistic regression analysis showed that diabetes(OR= 2.257) and microscopic hematuria(OR=5.324) were the risk factors of proteinuria (both P<0.05).And the risk factors for CKD were hypertension(OR= 1.459), coronary arth'erosclerotic heart disease(OR=3.290), chronic obstructive lung diseases(OR=2.094), malignant tumor(OR=2.072), hyperuricemia(OR= 1.928),anemia(OR=8.122)and hematuria( OR= 1.604) (all P<0.05).Conclusions The morbidity of CKD in Chinese elderly persons was 48.43%.And the related risk factors were diabetes,hypertension, hyperuricemia, coronary artherosclerotic heart disease and chronic obstructive lung disease.