CAJ | 학술논문

目的观察物理因子治疗对脑梗死患者血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)和脂联素水平的影响,并探讨其可能机制.方法 60例脑梗死患者随机分为物理因子治疗组(综合组)30例和单纯药物治疗组(药物组)30例,并于治疗前、后用乳胶凝集反应法测定血清hs-CRP水平、ELISA法测定血清TNF-α和脂联素含量.并选取30例健康体检者作为正常对照组(对照组).结果脑梗死患者治疗前,血清hs-CRP和TNF-α.水平明显较对照组高(P<0.01),脂联素水平明显较对照组低(P<0.01).综合组和药物组经治疗后,血清hs-CRP和TNF-α含量均较治疗前降低(P<0.01),脂联素水平较治疗前显著提高(P<0.01);综合组hs-CRP和TNF-α水平的下降较药物组更明显(P<0.05),脂联素水平提高也更显著(P<0.05).结论物理因子治疗脑梗死的机制可能与其降低患者血清hs-CRP、TNF-α含量及提高脂联素水平,促进内皮功能修复等因素有关.
목적 관찰물리인자치료대뇌경사환자혈청고민C반응단백(hs-CRP)、종류배사인자α(TNF-α)화지련소수평적영향,병탐토기가능궤제.방법 60례뇌경사환자수궤분위물리인자치료조(종합조)30례화단순약물치료조(약물조)30례,병우치료전、후용유효응집반응법측정혈청hs-CRP수평、ELISA법측정혈청TNF-α화지련소함량.병선취30례건강체검자작위정상대조조(대조조).결과 뇌경사환자치료전,혈청hs-CRP화TNF-α.수평명현교대조조고(P<0.01),지련소수평명현교대조조저(P<0.01).종합조화약물조경치료후,혈청hs-CRP화TNF-α함량균교치료전강저(P<0.01),지련소수평교치료전현저제고(P<0.01);종합조hs-CRP화TNF-α수평적하강교약물조경명현(P<0.05),지련소수평제고야경현저(P<0.05).결론 물리인자치료뇌경사적궤제가능여기강저환자혈청hs-CRP、TNF-α함량급제고지련소수평,촉진내피공능수복등인소유관.
Objective To observe the effects of physical agents therapy on serum hs-CRP, TNF-α andadiponectin in patients with cerebral infarction and the possible underlying mechanisms. Methods Sixty patientswith cerebral infarction were randomly and equally divided into two groups: 30 cases were treated with physical a-gents therapy ( physical therapy group) , and 30 with drugs only ( drug treated group). Thirty normal subjectsserved as the control group. The level of hs-CRP in the serum was determined by latex agglutination reaction, TNF-and adiponectin were determined by using ELISA before and after therapy. Results The levels of serum hs-CRP and TNF-α of patients with cerebral infarction before therapy were much higher than those of the control group,but adiponectin was significantly lower than those of the control group( P < 0.01 ). After therapy, the levels of ser-um hs-CRP and TNF-α were decreased and adiponectin was increased significantly in both treated groups ( P <0.01 ). Comparison with two treated groups showed that the levels of hs-CRP and TNF-α were lower and adiponec-tin was obviously higher in physical agents therapy group than those in the drug treated group ( P < 0.05 ). Con-clusion The patients with cerebral infarction have low level of serum adiponectin. Physical therapy might exertbeneficial effects on patients with cerebral infarction by the decreasing serum hs-CRP and TNF-α, as well as by ele-vating adiponectin.