合成化学
閤成化學
합성화학
CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
2010年
1期
134-136
,共3页
白金龙%王如金%刘立英%付德才
白金龍%王如金%劉立英%付德纔
백금룡%왕여금%류립영%부덕재
7-氨基-3-乙烯基头孢烷酸%Wittig%反应%酶解%中间体%药物合成
7-氨基-3-乙烯基頭孢烷痠%Wittig%反應%酶解%中間體%藥物閤成
7-안기-3-을희기두포완산%Wittig%반응%매해%중간체%약물합성
7-amiNO_3~--vinylcephalosporanic acid%Wittig reaction%enzymatic hydrolysis%intermediate%drug synthesis
以7-苯乙酰氨基-3-氯甲基头孢烷酸对甲氧基苄酯为原料经Wittig反应、水解、酶解三步反应合成重要的药物中间体--7-氨基-3-乙烯基头孢烷酸,总收率71.2%.其结构经~1H NMR和IR表征.
以7-苯乙酰氨基-3-氯甲基頭孢烷痠對甲氧基芐酯為原料經Wittig反應、水解、酶解三步反應閤成重要的藥物中間體--7-氨基-3-乙烯基頭孢烷痠,總收率71.2%.其結構經~1H NMR和IR錶徵.
이7-분을선안기-3-록갑기두포완산대갑양기변지위원료경Wittig반응、수해、매해삼보반응합성중요적약물중간체--7-안기-3-을희기두포완산,총수솔71.2%.기결구경~1H NMR화IR표정.
A key drug intermediate,7-amino-3-vinylcephalosporanic acid,was synthesized from 7-phenylacetamide-3-chloromethyl-3-cepham-4-carboxylic acid p-methoxybenzyl ester by a three-step reaction of Wittig reaction,hydrolysis and enzymatic hydrolysis.The total yield was 71.2%.The structure was characterized by ~1H NMR and IR.
