中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2011年
4期
283-286
,共4页
夏芳珍%陆颖理%陈奕%顾婷%余娇%赵丽娟%张惠新%杨裕国%吴万龄%张美芳%马蓓蕾
夏芳珍%陸穎理%陳奕%顧婷%餘嬌%趙麗娟%張惠新%楊裕國%吳萬齡%張美芳%馬蓓蕾
하방진%륙영리%진혁%고정%여교%조려연%장혜신%양유국%오만령%장미방%마배뢰
糖尿病,2型%心房利钠肽%醛固酮%内啡肽%钠离子
糖尿病,2型%心房利鈉肽%醛固酮%內啡肽%鈉離子
당뇨병,2형%심방리납태%철고동%내배태%납리자
Diabetes mellitus, type 2%Atrial natriuretic peptide%Aldosterone%Endmorphin% Na+
目的 研究饮食中Na+浓度及热量对糖尿病患者醛固酮(ALD)、心房利钠肽(ANP)及内啡肽(EM)分泌的影响.方法 57例T2DM患者,分别于禁食12h后的两个清晨给予高钠低热量及低钠高热量的食物,用放免法检测空腹和餐后2h血浆ALD、ANP及EM的浓度.结果 在摄入高钠低热量食物2h后,血浆ALD、EM浓度无明显变化,ANP显著增高;而摄入低钠高热量食物2h后,血浆EM、ALD显著降低,ANP无明显变化.在两次试验中,空腹状态下EM均与ANP、ALD呈正相关.结论 (1)T2ZDM患者血浆ALD对食物中摄入的Na+增加反应不敏感,ANP显著增高;(2)EM主要调节患者能量摄入,当患者摄入高热量食物后EM血浆浓度显著降低.
目的 研究飲食中Na+濃度及熱量對糖尿病患者醛固酮(ALD)、心房利鈉肽(ANP)及內啡肽(EM)分泌的影響.方法 57例T2DM患者,分彆于禁食12h後的兩箇清晨給予高鈉低熱量及低鈉高熱量的食物,用放免法檢測空腹和餐後2h血漿ALD、ANP及EM的濃度.結果 在攝入高鈉低熱量食物2h後,血漿ALD、EM濃度無明顯變化,ANP顯著增高;而攝入低鈉高熱量食物2h後,血漿EM、ALD顯著降低,ANP無明顯變化.在兩次試驗中,空腹狀態下EM均與ANP、ALD呈正相關.結論 (1)T2ZDM患者血漿ALD對食物中攝入的Na+增加反應不敏感,ANP顯著增高;(2)EM主要調節患者能量攝入,噹患者攝入高熱量食物後EM血漿濃度顯著降低.
목적 연구음식중Na+농도급열량대당뇨병환자철고동(ALD)、심방리납태(ANP)급내배태(EM)분비적영향.방법 57례T2DM환자,분별우금식12h후적량개청신급여고납저열량급저납고열량적식물,용방면법검측공복화찬후2h혈장ALD、ANP급EM적농도.결과 재섭입고납저열량식물2h후,혈장ALD、EM농도무명현변화,ANP현저증고;이섭입저납고열량식물2h후,혈장EM、ALD현저강저,ANP무명현변화.재량차시험중,공복상태하EM균여ANP、ALD정정상관.결론 (1)T2ZDM환자혈장ALD대식물중섭입적Na+증가반응불민감,ANP현저증고;(2)EM주요조절환자능량섭입,당환자섭입고열량식물후EM혈장농도현저강저.
Objective To examine the effects of the dietary sodium and caloric intake on plasma aldosterone (ALD), atrial natriuretic peptide (ANP) and endomorphin (EM) in type 2 diabetes mellitus (T2DM). Methods The 57 T2DM patients received the test diet with low calorie and high sodium, and after two days received the high caloric and low sodium diet. The blood samples were collected for ALD, ANP and EM examination by radioimmunoassay before and 2 hours after test diets. Results The test diet of high sodium and low calorie showed a increased ANP level (110.2±18.1 vs 86.0±20.6 ng/L, P＜0.01) and the similar ALD and EM levels (all P>0.05) as compared with pre-test diet. And the low sodium and high calorie diet was associated with a decreased levels of ALD (0.44±0.1 vs 0.57±0.2 μg/L, P＜0.01) and EM (43.5±12.3 vs 49.4±14.1 ng/L, P＜0.01) and a similar level of ANP (P＞0.05) compared with pre-test diet. Fasting EM level was positively correlated with ALD (γ=0.331, P=0.016) and ANP (γ=0.315, P=0.023). Conclusions In T2DM patients, plsma aldosterone level has no response to high sodium diet, but is sensitive to low sodium diet; and ANP level is sensitive to high sodium diet and has no response to low sodium diet. At fasting, EM is positively correlated with ALD and ANP.
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