CAJ | 학술논문

目的探讨烧伤患者侵袭性感染的细菌学监测和抗生素使用情况.方法 100例烧伤患者测定烧伤创面和焦痂细菌分类、敏感试验和及耐药情况.结果创面和焦痂下组织中分离出细菌382株,创面分离出细菌250株(65.4%)高于焦痂下组织分离出细菌132株(34.6%)(x~2=3.987,P＜0.05).革兰阴性(G-)菌227株(59.4%)高于革兰阳性(G+)菌155株(40.6%)(x~2=3.887,P＜0.05).G-杆菌中铜绿假单胞菌和肠杆菌科细菌为主要菌种,而G+球菌中金黄色葡萄球菌为主要菌种;亚胺硫霉素对铜绿假单胞菌耐药率(10.38%)明显低于庆大霉素(70.12%)(x~2=7.451,P＜0.01);苯唑西林对金黄色葡萄球菌耐药率(82.14%)明显高于万古霉素(5.35%)(x~2=7.548,P＜0.01).结论对烧伤患者伴G-杆菌感染宜采用亚胺硫霉素治疗,G+球菌感染者首选万古霉素.
목적 탐토소상환자침습성감염적세균학감측화항생소사용정황.방법 100례소상환자측정소상창면화초가세균분류、민감시험화급내약정황.결과 창면화초가하조직중분리출세균382주,창면분리출세균250주(65.4%)고우초가하조직분리출세균132주(34.6%)(x~2=3.987,P＜0.05).혁란음성(G-)균227주(59.4%)고우혁란양성(G+)균155주(40.6%)(x~2=3.887,P＜0.05).G-간균중동록가단포균화장간균과세균위주요균충,이G+구균중금황색포도구균위주요균충;아알류매소대동록가단포균내약솔(10.38%)명현저우경대매소(70.12%)(x~2=7.451,P＜0.01);분서서림대금황색포도구균내약솔(82.14%)명현고우만고매소(5.35%)(x~2=7.548,P＜0.01).결론 대소상환자반G-간균감염의채용아알류매소치료,G+구균감염자수선만고매소.
Objective To investigate the bacteriological monitoring and antibiotic use of invasive infection in patients with burns. Method The index of burn wound、 eschar distribution、 strains of bacteria, bacterial classification、sensitivity and drug resistance were determinated in 100 cases with burns. Results The wound and eschar 382 strain were isolated from the wound and eschar;The wound bacteria 250 strain(65.4%) were significantly higher than that eschar 132 strain (34.6%) (x~2 = 3. 987,P ＜ 0.05); Gram-negative (G -) 227 strain (59. 4%) were significantly higher than that Gram-positive(G +) 155 strain(40. 6%) (x~2 = 3. 887, P ＜ 0.05); Pseudomonas aeruginosa and Enterobacteriaceae in Gram-negative is major strains,while Staphylococcus aureus in Gram-positive is major strains;The Pseudomonas aeruginosa resistance rate(10.38%) was significantly lower than gentamicin(70. 12%) (x~2 =7. 451 ,P＜ 0.01) ;The rate of methicillin-resistant(82. 14%) for Staphylococcus aureus was significantly higher than that of vancomycin(5.35%) (x~2 =7.548 ,P ＜0.01). Conclusion The Gram-negative infection could treat with imipenem,Gram-positive infections could treat with vancomycin for patients with burns.