中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2009年
1期
9-13
,共5页
张权%张云亭%张敬%李威%宋修峰
張權%張雲亭%張敬%李威%宋脩峰
장권%장운정%장경%리위%송수봉
垂体大腺瘤%磁共振成像,功能性%弥散张量成像%视觉皮层%视放射
垂體大腺瘤%磁共振成像,功能性%瀰散張量成像%視覺皮層%視放射
수체대선류%자공진성상,공능성%미산장량성상%시각피층%시방사
Pituitary macroadenoma%Magnetic resonance imaging,functional%Diffusion tensorimaging%Visual cortex%Optic radiation
目的 采用弥散张量成像(DTI)和功能磁共振成像(fMRI)方法对垂体大腺瘤患者后视路的结构和功能进行评价,分析垂体大腺瘤对视放射和视觉皮层的影响.方法 采用1.5T磁共振扫描仪对23例垂体大腺瘤患者(患者组)及18名健康志愿者(对照组)进行组块设计的fMRI和DTI检查.fMRI刺激内容为全视野黑白翻转棋盘格,对照内容为黑色屏幕中心的白色"+",左右眼分别进行试验.采用SPM2进行fMRI数据后处理,通过组间分析方法分别获得左眼及右眼刺激下患者组与对照组间的激活差异图.DTI扫描采用13个弥散敏感梯度,b值为1000 s/mm2.采用Volume-one软件进行后处理,测量两侧视放射的FA值,分析两组间视放射FA值的差异.结果 在严格控制头动和机械噪声等影响因素后,最终各入组12例.患者组与对照组比较,初级视觉皮层激活范围及强度均明显缩小.且以对侧视觉皮层激活下降为主(P<0.05).患者组左侧及右侧视放射FA值均明显小于对照组(左侧:0.52±0.06比0.58±0.04,t=3.45,P<0.01;右侧:0.50±0.05比0.60±0.04,t=5.77,P<0.01).结论 垂体大腺瘤患者可发生后视路的微观结构改变和功能下降,而联合应用DTI和fMRI有助于早期了解这种脑结构与功能变化.
目的 採用瀰散張量成像(DTI)和功能磁共振成像(fMRI)方法對垂體大腺瘤患者後視路的結構和功能進行評價,分析垂體大腺瘤對視放射和視覺皮層的影響.方法 採用1.5T磁共振掃描儀對23例垂體大腺瘤患者(患者組)及18名健康誌願者(對照組)進行組塊設計的fMRI和DTI檢查.fMRI刺激內容為全視野黑白翻轉棋盤格,對照內容為黑色屏幕中心的白色"+",左右眼分彆進行試驗.採用SPM2進行fMRI數據後處理,通過組間分析方法分彆穫得左眼及右眼刺激下患者組與對照組間的激活差異圖.DTI掃描採用13箇瀰散敏感梯度,b值為1000 s/mm2.採用Volume-one軟件進行後處理,測量兩側視放射的FA值,分析兩組間視放射FA值的差異.結果 在嚴格控製頭動和機械譟聲等影響因素後,最終各入組12例.患者組與對照組比較,初級視覺皮層激活範圍及彊度均明顯縮小.且以對側視覺皮層激活下降為主(P<0.05).患者組左側及右側視放射FA值均明顯小于對照組(左側:0.52±0.06比0.58±0.04,t=3.45,P<0.01;右側:0.50±0.05比0.60±0.04,t=5.77,P<0.01).結論 垂體大腺瘤患者可髮生後視路的微觀結構改變和功能下降,而聯閤應用DTI和fMRI有助于早期瞭解這種腦結構與功能變化.
목적 채용미산장량성상(DTI)화공능자공진성상(fMRI)방법대수체대선류환자후시로적결구화공능진행평개,분석수체대선류대시방사화시각피층적영향.방법 채용1.5T자공진소묘의대23례수체대선류환자(환자조)급18명건강지원자(대조조)진행조괴설계적fMRI화DTI검사.fMRI자격내용위전시야흑백번전기반격,대조내용위흑색병막중심적백색"+",좌우안분별진행시험.채용SPM2진행fMRI수거후처리,통과조간분석방법분별획득좌안급우안자격하환자조여대조조간적격활차이도.DTI소묘채용13개미산민감제도,b치위1000 s/mm2.채용Volume-one연건진행후처리,측량량측시방사적FA치,분석량조간시방사FA치적차이.결과 재엄격공제두동화궤계조성등영향인소후,최종각입조12례.환자조여대조조비교,초급시각피층격활범위급강도균명현축소.차이대측시각피층격활하강위주(P<0.05).환자조좌측급우측시방사FA치균명현소우대조조(좌측:0.52±0.06비0.58±0.04,t=3.45,P<0.01;우측:0.50±0.05비0.60±0.04,t=5.77,P<0.01).결론 수체대선류환자가발생후시로적미관결구개변화공능하강,이연합응용DTI화fMRI유조우조기료해저충뇌결구여공능변화.
Objective To evaluate the anatomy and function of post visual pathways in patients with pituitary macroadenoma by functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) and analyze the effect of pituitary macroadenoma on optic radiation and visual cortex. Methods Twenty-three patients with pituitary macroadenoma(patients group) and eighteen matched healthy volunteers (control group) were recmited in this study. Block-designed fMRI and DTI were performed with 1.5 T magnetic resonance scanner. During fMRI examination, black and white check board and white "+" in black screen center were used as stimulus and control respectively. Bilateral eyes in two groups received stimulus individually. The fMRI data were processed with SPM2. Different mappings between two groups during bilateral eyes examination were obtained respectively with inter-group analysis. Thirteen diffusion sensitive directions were used during DTI examination with b value 1000 s/mm2. "Volume-one" software was used to process the DTI data, and FA value of bilateral optic radiation was measured. The difference of the FA value of optic radiation between two groups was compared. Results The numbers of patients selected for group analysis in left and right eye examination were both twelve after head motion and mechanical noise effects were ruled out. Compared to control group, activated extent and intensity of primary visual cortex decreased in patients group, especially in contralateral visual cortex (P<0.05). The FA value of bilateral optic radiation in patients group decreased obviously compared with control group(left: 0.52±0.06 vs 0.58±0.04, t=3.45, P<0.01; fight: 0.50 ± 0.05 vs 0.60 ± 0.04, t=5.77, P<0.01). Conclusions The patients with pituitary macroadenoma may present changed microstructure and decreased function of post visual pathways. Combinated application of fMRI and DTI is an effective method for early detecting the changes of cerebral structures and function.
