CAJ | 학술논문

评估应用美国糖尿病协会(ADA)近日推荐的HbA1C标准对早期探查肥胖儿童糖代谢紊乱的作用。293名肥胖儿童均行口服葡萄糖耐量试验(OGTT)，以其工作特征曲线(ROC)评价空腹血糖(FPG)和HbA1C探查糖耐量异常的敏感性和特异性。结果显示，基于传统的血糖标准，本组研究对象2型糖尿病的患病率为3.8％、糖尿病前期的患病率为16.0％。加入HbA1C标准后有4.1％的患者符合2型糖尿病诊断、25.6％的患者可列入糖尿病高风险人群。以OGTT为金标准，HbA1C识别糖耐量异常的能力明显强于FPG，ROC曲线下面积分别为0.875和0.713( P＜0.01)。采用ADA推荐的HbA1C≥5.7％、FPG≥5.6mmol/L的切点识别糖耐量异常的敏感性和特异性分别为60.5％和86.8％、30.5％和94.0％。
평고응용미국당뇨병협회(ADA)근일추천적HbA1C표준대조기탐사비반인동당대사문란적작용。293명비반인동균행구복포도당내량시험(OGTT)，이기공작특정곡선(ROC)평개공복혈당(FPG)화HbA1C탐사당내량이상적민감성화특이성。결과현시，기우전통적혈당표준，본조연구대상2형당뇨병적환병솔위3.8％、당뇨병전기적환병솔위16.0％。가입HbA1C표준후유4.1％적환자부합2형당뇨병진단、25.6％적환자가렬입당뇨병고풍험인군。이OGTT위금표준，HbA1C식별당내량이상적능력명현강우FPG，ROC곡선하면적분별위0.875화0.713( P＜0.01)。채용ADA추천적HbA1C≥5.7％、FPG≥5.6mmol/L적절점식별당내량이상적민감성화특이성분별위60.5％화86.8％、30.5％화94.0％。
The validity of the recently recommended HbA1C criterion by the American Diabetes Association (ADA) in identification of dysglycemia in children with obesity was evaluated. 293 obese children underwent oral glucose tolerance test. Receiver operating characteristic ( ROC ) curve analysis was used to examine the sensitivity and specificity of fasting plasma glucose (FPG) and HbA1C in identifying dysglycemia. The results showed that the prevalence of type 2 diabetes mellitus (T2DM) was 3.8％ and prediabetes 16. 0％ based on plasma glucose standard. 4. 1％ and 25.6％ were categorized as T2DM and “at high risk of diabetes mellitus” based on both HbA1C and plasma glucose criteria. HbA1C was more efficacious than FPG in detecting abnormal glucose tolerance as shown by the areas under the curve in ROC of 0. 875 and 0. 713 respectively (P＜0. 01 ). The sensitivity and specificity were 60. 5％ and 86. 8％ at HbA1C ≥5.7％, and 30. 5％ and 94.0％ at FPG ≥ 5.6 mmol/L.