中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
15期
14-16
,共3页
唐碧莲%陆长东%何爱兰%古晓琳
唐碧蓮%陸長東%何愛蘭%古曉琳
당벽련%륙장동%하애란%고효림
红霉素%婴儿,早产%母乳喂养%不耐受
紅黴素%嬰兒,早產%母乳餵養%不耐受
홍매소%영인,조산%모유위양%불내수
Erythromycin%Infant,premature%Breast feeding%Intolerance
目的 探讨小剂量红霉素预防早产儿喂养不耐受的疗效及安全性.方法 选择早产儿胎龄30～31周52例和胎龄32～34周68例,分别在两个胎龄内各按随机分配的原则均分为用药组和对照组,其中用药组于生后第2天常规给予红霉素3 mg/(kg·d),1次/d,共10 d;对照组给予5%葡萄糖注射液3 ml/(kg·d).结果 在胎龄30～31周早产儿用药组和对照组达全肠内喂养时间、恢复出生体重时间、住院时间、喂养不耐受发生率比较差异均无统计学意义(P>0.05).而在胎龄32～34周早产儿用药组与对照组达全肠内喂养时间[分别为(13.8±4.5)、(17.2±4.2)d]、恢复出生体重时间[分别为(10.5±1.6)、(13.8±1.5)d]、住院时间[分别为(28.5±6.8)、(35.5±7.2)d]及喂养不耐受发生率[分别为17.6%(6/34)、35.3%(12/34)]差异均有统计学意义(P<0.05).结论 小剂量红霉素预防早产儿喂养不耐受.对胎龄32～34周的早产儿是安全有效的,但对胎龄30～31周的早产儿效果却不显著.
目的 探討小劑量紅黴素預防早產兒餵養不耐受的療效及安全性.方法 選擇早產兒胎齡30～31週52例和胎齡32～34週68例,分彆在兩箇胎齡內各按隨機分配的原則均分為用藥組和對照組,其中用藥組于生後第2天常規給予紅黴素3 mg/(kg·d),1次/d,共10 d;對照組給予5%葡萄糖註射液3 ml/(kg·d).結果 在胎齡30～31週早產兒用藥組和對照組達全腸內餵養時間、恢複齣生體重時間、住院時間、餵養不耐受髮生率比較差異均無統計學意義(P>0.05).而在胎齡32～34週早產兒用藥組與對照組達全腸內餵養時間[分彆為(13.8±4.5)、(17.2±4.2)d]、恢複齣生體重時間[分彆為(10.5±1.6)、(13.8±1.5)d]、住院時間[分彆為(28.5±6.8)、(35.5±7.2)d]及餵養不耐受髮生率[分彆為17.6%(6/34)、35.3%(12/34)]差異均有統計學意義(P<0.05).結論 小劑量紅黴素預防早產兒餵養不耐受.對胎齡32～34週的早產兒是安全有效的,但對胎齡30～31週的早產兒效果卻不顯著.
목적 탐토소제량홍매소예방조산인위양불내수적료효급안전성.방법 선택조산인태령30～31주52례화태령32～34주68례,분별재량개태령내각안수궤분배적원칙균분위용약조화대조조,기중용약조우생후제2천상규급여홍매소3 mg/(kg·d),1차/d,공10 d;대조조급여5%포도당주사액3 ml/(kg·d).결과 재태령30～31주조산인용약조화대조조체전장내위양시간、회복출생체중시간、주원시간、위양불내수발생솔비교차이균무통계학의의(P>0.05).이재태령32～34주조산인용약조여대조조체전장내위양시간[분별위(13.8±4.5)、(17.2±4.2)d]、회복출생체중시간[분별위(10.5±1.6)、(13.8±1.5)d]、주원시간[분별위(28.5±6.8)、(35.5±7.2)d]급위양불내수발생솔[분별위17.6%(6/34)、35.3%(12/34)]차이균유통계학의의(P<0.05).결론 소제량홍매소예방조산인위양불내수.대태령32～34주적조산인시안전유효적,단대태령30～31주적조산인효과각불현저.
Objective To evaluate the efficacy and safety of low-dose erythromycin for the prevention of feeding intolerance in preterm infants. Methods Fifty-two preterm infants (30-31 weeks' GA group) and 68 preterm infants (32-34 weeks' GA group) were randomly subdivided into prevention groups and control groups. From the second day the prevention groups received intravenously erythromycin [3 mg /(kg·d)] for 10 days,the control groups received placebo of glucose. Results In 30-31 weeks' GA group,days to achieve full enteral feeding (DAFEF) ,days to regain birth weight (DRBW) and duration of hospitalization (DH) were shorter in the prevention group as compared to those in the control group, the incidence of feeding intolerance was lower too,but there was no significant difference (P >0.05). In 32-34 weeks' GA group, DAFEF [(13.8±4.5) d],DRBW [(10.5±1.6) d],DH [(28.5±6.8) d] were significantly shorter in the prevention group than those in the control group [(17.2±4.2), (13.8±1.5), (35.5±7.2) d],the incidence of feeding intolerance in the prevention group was lower too[ 17.6%(6/34) vs 35.3%( 12/34) ], there was significant difference (P < 0.05 ). Conclusion In 32-34 weeks' GA, low-dose erythromycin can be a safe and effective method to promote food tolerance in preterm infants, but not sure in 30-31 weeks' GA.
