中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
16期
23-25
,共3页
胃肿瘤%肿瘤标记%生物学%病理学特征
胃腫瘤%腫瘤標記%生物學%病理學特徵
위종류%종류표기%생물학%병이학특정
Stomach neoplasms%Tumor markers,biological%Pathological characteristics
目的 探讨胃癌患者术前血清肿瘤标志物CEA、CA125、CA19-9的水平与临床病理学特征的关系.方法 采用电化学发光免疫分析法检测107例胃癌患者术前血清中CEA、CA125、CA19-9水平.结果 胃癌患者血清中CEA、CA125、CA19-9水平与性别、年龄及肿瘤发生部位之间均无密切相关.有淋巴结转移的胃癌患者血清中CEA、CA125、CA19-9水平高于无淋巴结转移的胃癌患者.CEA、CA125、CA19-9水平随浸润程度加深及肿瘤的增大而增高.分化程度越低,CA125水平越高,而CEA、CA19-9水平与分化程度无显著相关性.胃癌患者血清中CA125、CEA、CA19-9三者之间存在正相关,CA125与CA19-9相关系数为0.623(P<0.01),CA125与CEA相关系数为0.572(P<0.01),CA19-9与CEA相关系数为0.412(P<0.01).结论 胃癌患者血清中CEA、CA125、CA19-9水平与胃癌病灶的大小、浸润深度及有无淋巴结转移等显著相关,且血清中CA125、CEA、CA19-9三者之间存在正相关性,故术前检测血清中三者的水平能够为胃癌患者治疗方案的制订提供一定的参考.
目的 探討胃癌患者術前血清腫瘤標誌物CEA、CA125、CA19-9的水平與臨床病理學特徵的關繫.方法 採用電化學髮光免疫分析法檢測107例胃癌患者術前血清中CEA、CA125、CA19-9水平.結果 胃癌患者血清中CEA、CA125、CA19-9水平與性彆、年齡及腫瘤髮生部位之間均無密切相關.有淋巴結轉移的胃癌患者血清中CEA、CA125、CA19-9水平高于無淋巴結轉移的胃癌患者.CEA、CA125、CA19-9水平隨浸潤程度加深及腫瘤的增大而增高.分化程度越低,CA125水平越高,而CEA、CA19-9水平與分化程度無顯著相關性.胃癌患者血清中CA125、CEA、CA19-9三者之間存在正相關,CA125與CA19-9相關繫數為0.623(P<0.01),CA125與CEA相關繫數為0.572(P<0.01),CA19-9與CEA相關繫數為0.412(P<0.01).結論 胃癌患者血清中CEA、CA125、CA19-9水平與胃癌病竈的大小、浸潤深度及有無淋巴結轉移等顯著相關,且血清中CA125、CEA、CA19-9三者之間存在正相關性,故術前檢測血清中三者的水平能夠為胃癌患者治療方案的製訂提供一定的參攷.
목적 탐토위암환자술전혈청종류표지물CEA、CA125、CA19-9적수평여림상병이학특정적관계.방법 채용전화학발광면역분석법검측107례위암환자술전혈청중CEA、CA125、CA19-9수평.결과 위암환자혈청중CEA、CA125、CA19-9수평여성별、년령급종류발생부위지간균무밀절상관.유림파결전이적위암환자혈청중CEA、CA125、CA19-9수평고우무림파결전이적위암환자.CEA、CA125、CA19-9수평수침윤정도가심급종류적증대이증고.분화정도월저,CA125수평월고,이CEA、CA19-9수평여분화정도무현저상관성.위암환자혈청중CA125、CEA、CA19-9삼자지간존재정상관,CA125여CA19-9상관계수위0.623(P<0.01),CA125여CEA상관계수위0.572(P<0.01),CA19-9여CEA상관계수위0.412(P<0.01).결론 위암환자혈청중CEA、CA125、CA19-9수평여위암병조적대소、침윤심도급유무림파결전이등현저상관,차혈청중CA125、CEA、CA19-9삼자지간존재정상관성,고술전검측혈청중삼자적수평능구위위암환자치료방안적제정제공일정적삼고.
Objective To investigate the relationship between the serum levels of CEA,cAl25,CA19-9 and clinical pathological characteristics in gastric cancel patients.Method The serum levels of CEA,CA125 and CA19-9 in 107 gastric cancer patients before the surgery were detected by electrochemiluminescence immunoassay.Results The preoperative seurm levels of CEA,CA125 and CA19-9 were not correlated with sex,age and the location of the tumor.The serum level of CEA,CA125 and CA19-9 in patients with lymph node metastasis were higher than those in patients without lymph node metastasis.The serum levels of CEA,CA125 and CA19-9 were positively correlated with the depth of tumor invasion and the size of the tumor.The serum levels of CA125 were correlated with the degrees of differentiation.Thehigher the CA125 levels,the lower the degrees of differentiation.But the levels of CEA and CA19-9 were not correlated with differentiation.There were positive.correlations among the serum levels of CEA,CA125 and CA19-9.The correlation coefficient of CA125 and CA19-9 was 0.623(P<0.01),CA125 and CEA was 0.572(P<0.01),CA19-9 and CEA was 0.412(P<0.01).Conclusions The serum levels of CEA,CA125 and CA19-9 in gastric cancer patients are significantly related with the size of the tumor,the depta of tumor invasion and lymph node metastasis.The preoperative serum levels of CEA,CA125 and CA19-9 can provide some reference for formulating the treatment of the gastric cancer patients.
