中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2009年
3期
344-346
,共3页
李军川%竺红宇%陈廷煊%代桂华%邹兰英%赵会传
李軍川%竺紅宇%陳廷煊%代桂華%鄒蘭英%趙會傳
리군천%축홍우%진정훤%대계화%추란영%조회전
乳腺肿瘤/遗传学%转化生长因子β%基因,BRCA2%预后
乳腺腫瘤/遺傳學%轉化生長因子β%基因,BRCA2%預後
유선종류/유전학%전화생장인자β%기인,BRCA2%예후
Breast neoplasms/GE%Transforming growth factor beta%Genes,BRCA2%Prognosis
目的 探讨乳腺癌TGF-β1和BRCA2的表达与临床因素的相关性.方法 应用免疫组化S-P法检测67例乳腺癌中TGF-β1、BRCA2和HER2、EB、PR的表达,并选择年龄、组织学分级、淋巴结转移等进行单因素非条件logistic回归分析.结果 TGF-β1和BRCA2在乳腺癌组织中表达,参与分析的变量中,与BRCA2明显相关的变量为HER2、TGF-β1,与TGF-β1相关的变量为BRCA2.结论 乳腺癌BRCA2过表达与TGF-β1、HER2表达相关,三者表达有一定协同性,联合检测可指导治疗和预后判断.
目的 探討乳腺癌TGF-β1和BRCA2的錶達與臨床因素的相關性.方法 應用免疫組化S-P法檢測67例乳腺癌中TGF-β1、BRCA2和HER2、EB、PR的錶達,併選擇年齡、組織學分級、淋巴結轉移等進行單因素非條件logistic迴歸分析.結果 TGF-β1和BRCA2在乳腺癌組織中錶達,參與分析的變量中,與BRCA2明顯相關的變量為HER2、TGF-β1,與TGF-β1相關的變量為BRCA2.結論 乳腺癌BRCA2過錶達與TGF-β1、HER2錶達相關,三者錶達有一定協同性,聯閤檢測可指導治療和預後判斷.
목적 탐토유선암TGF-β1화BRCA2적표체여림상인소적상관성.방법 응용면역조화S-P법검측67례유선암중TGF-β1、BRCA2화HER2、EB、PR적표체,병선택년령、조직학분급、림파결전이등진행단인소비조건logistic회귀분석.결과 TGF-β1화BRCA2재유선암조직중표체,삼여분석적변량중,여BRCA2명현상관적변량위HER2、TGF-β1,여TGF-β1상관적변량위BRCA2.결론 유선암BRCA2과표체여TGF-β1、HER2표체상관,삼자표체유일정협동성,연합검측가지도치료화예후판단.
Objective To explore the relationship between TGF-beta1,BRCA2,HER2,ER,PR and clinical factors in breast cancer.Methods The expression of TGF-beta1,BRCA2,HEB2,ER,PB in 67 cases breast carcinoma were detected by immunohistochemistry staining SP method.The correlation of the results with other parameters which included age,pathohistological grade,status of auxiliary lymph nodes were analyzed by mono-factor unconditional logistic regression analysis.Results The expression of TGF-beta1 was correlated with BRCA2.and the expression of BRCA2 was correlated with TGF-beta1 and c-erbB-2 in breast cancer.Condusion Overexpression of BRCA2 was related with TGF-beta1 and HER2 in breast carcinoma.It was useful in breast carcinoma prognosis by detecting these three factors.
