中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
6期
846-848
,共3页
糖尿病,2型%胰岛素%阿卡波糖
糖尿病,2型%胰島素%阿卡波糖
당뇨병,2형%이도소%아잡파당
Diabetes mellitus,type 2%Insulin%Acarbose
目的 观察地特胰岛素联合阿卡波糖治疗2型糖尿病的临床疗效.方法 对32例经预混精蛋白生物合成人胰岛素治疗血糖控制不佳的2型糖尿病患者,采用地特胰岛素每天1次注射,联合阿卡波糖,每天3次口服,治疗12周,采用自身对照,观察治疗前后三餐前、三餐后、睡前血糖、糖化血红蛋白(HbA1c)水平、体质量指数(BMI)变化及低血糖发生情况、患者治疗依从性和满意率.结果 治疗后三餐前、三餐后及睡前血糖、HbA1c均比治疗前明显下降(t=11.212、14.997、10.863、17.950、11.108、14.034、12.422、22.764,均P＜0.01),日间低血糖发生率3.1％,无夜间症状性低血糖发生,BMI有所下降,但差异均无统计学意义(均P＞0.05),患者治疗依从性、满意率均较治疗前提高(x2=10.255、9.143,均P＜0.01).结论 地特胰岛素联合阿卡波糖可有效控制血糖,低血糖发生率低,不增加体质量,患者依从性好,满意度高.
目的 觀察地特胰島素聯閤阿卡波糖治療2型糖尿病的臨床療效.方法 對32例經預混精蛋白生物閤成人胰島素治療血糖控製不佳的2型糖尿病患者,採用地特胰島素每天1次註射,聯閤阿卡波糖,每天3次口服,治療12週,採用自身對照,觀察治療前後三餐前、三餐後、睡前血糖、糖化血紅蛋白(HbA1c)水平、體質量指數(BMI)變化及低血糖髮生情況、患者治療依從性和滿意率.結果 治療後三餐前、三餐後及睡前血糖、HbA1c均比治療前明顯下降(t=11.212、14.997、10.863、17.950、11.108、14.034、12.422、22.764,均P＜0.01),日間低血糖髮生率3.1％,無夜間癥狀性低血糖髮生,BMI有所下降,但差異均無統計學意義(均P＞0.05),患者治療依從性、滿意率均較治療前提高(x2=10.255、9.143,均P＜0.01).結論 地特胰島素聯閤阿卡波糖可有效控製血糖,低血糖髮生率低,不增加體質量,患者依從性好,滿意度高.
목적 관찰지특이도소연합아잡파당치료2형당뇨병적림상료효.방법 대32례경예혼정단백생물합성인이도소치료혈당공제불가적2형당뇨병환자,채용지특이도소매천1차주사,연합아잡파당,매천3차구복,치료12주,채용자신대조,관찰치료전후삼찬전、삼찬후、수전혈당、당화혈홍단백(HbA1c)수평、체질량지수(BMI)변화급저혈당발생정황、환자치료의종성화만의솔.결과 치료후삼찬전、삼찬후급수전혈당、HbA1c균비치료전명현하강(t=11.212、14.997、10.863、17.950、11.108、14.034、12.422、22.764,균P＜0.01),일간저혈당발생솔3.1％,무야간증상성저혈당발생,BMI유소하강,단차이균무통계학의의(균P＞0.05),환자치료의종성、만의솔균교치료전제고(x2=10.255、9.143,균P＜0.01).결론 지특이도소연합아잡파당가유효공제혈당,저혈당발생솔저,불증가체질량,환자의종성호,만의도고.
Objective To observe the effect of insulin detemir combined with acarbose in treatment of patients with type 2 diabetes (T2DM).Methods 32 T2DM patients whose blood glucose control was poor receiving twice daily isophane protamine biosynthetic human insulin( Novolin 30R) combined or not combined with oral hypoglycemic drugs,were switched to receive insulin detemir injection once daily and oral acarbose three times daily for 12 weeks.By self-contrasted method,observed blood glucose before and after three meals,before sleeping,glycated hemoglobin ( HbA1c),change of body mass index( BMI),incidence of hypoglycemia,compliance and satisfaction of patients (by questionnaire) before and after treatment.Results After treatment,the blood glucose before and after three meals,before sleeping and HbA1 c declined sigmifieatly ( t =11.212,14.997,10.863,17.950,11.108,14.034,12.422,22.764,all P ＜0.01 )compared to state before treatment.The rate of hypoglycemia in the day was 3.1％,without nocturnal symptoms of hypoglycemia.BMI had certain declining,but there was no statistical significance (P ＞ 0.05).The compliance and satisfaction of patients were in a higher rate (x2 =10.255,9.143,all P ＜ 0.01 ).Conclusion Insulin detemir combined with acarbose could effectively control the blood glucose,incidence of hypoglycemia,without increasing body mass,achieve good compliance and satisfaction of patients.
