南方医科大学学报
南方醫科大學學報
남방의과대학학보
JOURNAL OF SOUTHERN MEDICAL UNIVERSITY
2009年
10期
2027-2029
,共3页
徐忠东%何伟雄%赵一凡%夏淑轩%何波%杨涛%曹德雄%彭书崚%李珏%曹铭辉
徐忠東%何偉雄%趙一凡%夏淑軒%何波%楊濤%曹德雄%彭書崚%李玨%曹銘輝
서충동%하위웅%조일범%하숙헌%하파%양도%조덕웅%팽서릉%리각%조명휘
左西孟旦%心力衰竭%B型利钠肽%Meta分析
左西孟旦%心力衰竭%B型利鈉肽%Meta分析
좌서맹단%심력쇠갈%B형리납태%Meta분석
levosimendan%heart failure%B-type natriuretic peptide%meta-analysis
目的 Meta分析左西孟旦对失代偿心衰患者B型利钠肽(BNP)水平的影响,并评价左两孟旦在左心衰治疗中的疗效.方法 采用Meta分析法对收集到的相关文献进行严格的定量分析.结果 左西孟旦静脉用药后24 h时BNP平均降低337.66pg/ml,其95%CI为(-296.30,-379.02);48 h时平均降低259.92 pg/ml,其95%CI为(-195.76,-324.08);第1周平均降低123.09 pg/ml,其95%CI为(-53.32,-195.86).各时点心功能与用药前相比约分别增加了29%、22%、10%.结论 左西孟旦能改善失代偿心力衰竭患者心功能,显著降低血浆BNP水平.
目的 Meta分析左西孟旦對失代償心衰患者B型利鈉肽(BNP)水平的影響,併評價左兩孟旦在左心衰治療中的療效.方法 採用Meta分析法對收集到的相關文獻進行嚴格的定量分析.結果 左西孟旦靜脈用藥後24 h時BNP平均降低337.66pg/ml,其95%CI為(-296.30,-379.02);48 h時平均降低259.92 pg/ml,其95%CI為(-195.76,-324.08);第1週平均降低123.09 pg/ml,其95%CI為(-53.32,-195.86).各時點心功能與用藥前相比約分彆增加瞭29%、22%、10%.結論 左西孟旦能改善失代償心力衰竭患者心功能,顯著降低血漿BNP水平.
목적 Meta분석좌서맹단대실대상심쇠환자B형리납태(BNP)수평적영향,병평개좌량맹단재좌심쇠치료중적료효.방법 채용Meta분석법대수집도적상관문헌진행엄격적정량분석.결과 좌서맹단정맥용약후24 h시BNP평균강저337.66pg/ml,기95%CI위(-296.30,-379.02);48 h시평균강저259.92 pg/ml,기95%CI위(-195.76,-324.08);제1주평균강저123.09 pg/ml,기95%CI위(-53.32,-195.86).각시점심공능여용약전상비약분별증가료29%、22%、10%.결론 좌서맹단능개선실대상심력쇠갈환자심공능,현저강저혈장BNP수평.
Objective To conduct a meta-analysis of the effect of levosimendan on B-type natriuretic peptide (BNP) levels and evaluate the therapeutic effect of levosimendan on advanced heart failure. Methods A meta-analysis was performed on the selected data to analyze the effect of levosimendan on BNP levels. Results Levosimendan decreased BNP by a mean of 337.66 [95%CI (-296.30, -379.02)] pg/ml 24 h after the administration, and by 259.92 [95%CI (-195.76, -324.08)] pg/ml at 48 h, and by 123.09 [95%C1 (-53.32 ,-195.86)] pg/ml at 1 week. Levosimendan resulted in improvements of the cardiac function by about 29%, 22%, and 10% at 24 h, 48 h and 1 week after the administration. Conclusion Levosimendan produces favorable effects on the cardiac functions and BNP levels.
