CAJ | 학술논문

目的探讨CO2气腹对肝硬化兔肝功能及血清一氧化氮NO的影响及可能机制.方法制作兔肝硬化模型,闭合法建立气腹,分别于术中不同压力和术前、术后不同时间采取静脉血检测血清ALT,AST及NO的含量.结果常规气腹压(11 mmHg)下正常兔血清ALT,AST及NO含量气腹术后一定时间内较气腹前轻度增高,7d基本恢复.肝硬化兔血清ALT,AST气腹后增高明显,7d不能恢复正常,NO气腹前后始终无明显变化.结论肝硬变条件下,一定的CO2气腹压力对肝功能的损害较大,血清NO反应不敏感,不能反应性增高.
목적탐토CO2기복대간경화토간공능급혈청일양화담NO적영향급가능궤제.방법제작토간경화모형,폐합법건립기복,분별우술중불동압력화술전、술후불동시간채취정맥혈검측혈청ALT,AST급NO적함량.결과상규기복압(11 mmHg)하정상토혈청ALT,AST급NO함량기복술후일정시간내교기복전경도증고,7d기본회복.간경화토혈청ALT,AST기복후증고명현,7d불능회복정상,NO기복전후시종무명현변화.결론간경변조건하,일정적CO2기복압력대간공능적손해교대,혈청NO반응불민감,불능반응성증고.
[Objective] To study the effect of CO2 pneumoperitoneum on liver function and serum nitric oxide(NO) in cirrhosis rabbits and the mechanism. [Methods] The CO2 pneumoperitoneum of different pressure and duration was established by closed in model of cirrhosis rabbits. The venous blood sample was taken respectively to analyze liver function and NO. [Results] The level of serum alanine aminotransferase(ALT), aspartate aminotransferase (AST) and NO were slightly higher in limited time postoperative compared to the preoperative in normal rabbits, by the 7th day of postoperation, the level of both enzymes returned to normal values. In cirrhosis rabbits, ALT, AST postoperative increased significantly compared to preoperative levels and didn't returned even the 7th day of postoperation, but the level of NO had no significant differences all times. [Conclusions] CO2 pneumoperitoneum has a serious damage to the liver function in cirrhotic liver, but serum NO response insensitively and can't increase correspondingly.