CAJ | 학술논문

为了适应环境,很多动物在长期的进化过程中演化出了丰富的毒素及相关分泌物.这些物质中包含了高活性、作用专一的蛋白和多肽.由于它们作用的特异性和专一性,成为蛋白质多肽结构与功能研究的良好模型,也成为研究人类自身生理病理机制的工具和线索,同时也足开发临床诊断试剂和治疗药物的天然宝库.该文综述了中国科学院昆明动物研究所30多年来立足于我国丰富的有毒动物资源,对陆生有毒动物,包括蛇毒、两柄类皮肤分泌物及节肢动物唾液腺分泌物等的主要研究工作,总结了从单一成分到组学研究、从理化性质到人类疾病机理、从粗毒利用到理性药物设计等的发展历程,并对今后的研究提出一些建议.
위료괄응배경,흔다동물재장기적진화과정중연화출료봉부적독소급상관분비물.저사물질중포함료고활성、작용전일적단백화다태.유우타문작용적특이성화전일성,성위단백질다태결구여공능연구적량호모형,야성위연구인류자신생리병리궤제적공구화선색,동시야족개발림상진단시제화치료약물적천연보고.해문종술료중국과학원곤명동물연구소30다년래립족우아국봉부적유독동물자원,대륙생유독동물,포괄사독、량병류피부분비물급절지동물타액선분비물등적주요연구공작,총결료종단일성분도조학연구、종이화성질도인류질병궤리、종조독이용도이성약물설계등적발전역정,병대금후적연구제출일사건의.
Many animals produced a diversity of venoms and secretions to adapt the changes of environments through the long history of evolution. The components including a large quantity of specific and highly active peptides and proteins have become good research models for protein structure-function and also served as tools and novel clues for illustration of human disease mechanisms. At the same time, they are rich natural resources for new drug development. Through the valuable venomous animal resources of China, researchers at the Kunming Institute of Zoology, CAS have carried out animal toxin research over 30 years. This paper reviews the main work conducted on snake venoms, amphibian and insect secretions, and the development from single component to venomics, from biochemical characterization to human disease mechanisms, from crude venom to rational drug design along with a short perspective on future studies.