国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2008年
4期
292-295
,共4页
模式识别受体%Toll样受体%树突状细胞相关性C型凝集素-1%真菌性/免疫学
模式識彆受體%Toll樣受體%樹突狀細胞相關性C型凝集素-1%真菌性/免疫學
모식식별수체%Toll양수체%수돌상세포상관성C형응집소-1%진균성/면역학
Pattern recognition receptors%Toll-like receptors%Dendritic cell-associated C-type hctin-1%Mycoses/Immunology
真菌感染机体后,通过模式识别作用及细胞内信号传导,启动固有免疫和适应性免疫应答.模式识别作用足抗真菌免疫的始动环节,Toll样受体(TLRs)和树突状细胞相关性C型凝集素-1(Dectin-1)是参与抗真菌免疫的主要模式识别受体(RPP).两者活化后启动机体免疫应答,产生各种细胞因子和趋化因子,并直接诱导巨噬细胞、自然杀伤细胞吞噬和杀灭病原体.TLRs和Dectin-1的信号传导、抗真菌感染的免疫机制以及两者之间的相互作用等已成为目前研究的热点.
真菌感染機體後,通過模式識彆作用及細胞內信號傳導,啟動固有免疫和適應性免疫應答.模式識彆作用足抗真菌免疫的始動環節,Toll樣受體(TLRs)和樹突狀細胞相關性C型凝集素-1(Dectin-1)是參與抗真菌免疫的主要模式識彆受體(RPP).兩者活化後啟動機體免疫應答,產生各種細胞因子和趨化因子,併直接誘導巨噬細胞、自然殺傷細胞吞噬和殺滅病原體.TLRs和Dectin-1的信號傳導、抗真菌感染的免疫機製以及兩者之間的相互作用等已成為目前研究的熱點.
진균감염궤체후,통과모식식별작용급세포내신호전도,계동고유면역화괄응성면역응답.모식식별작용족항진균면역적시동배절,Toll양수체(TLRs)화수돌상세포상관성C형응집소-1(Dectin-1)시삼여항진균면역적주요모식식별수체(RPP).량자활화후계동궤체면역응답,산생각충세포인자화추화인자,병직접유도거서세포、자연살상세포탄서화살멸병원체.TLRs화Dectin-1적신호전도、항진균감염적면역궤제이급량자지간적상호작용등이성위목전연구적열점.
The innate and adaptive immune are initiated by pattern recognition and intracelhlar signal transduction after fungal pathogen invasion.Pattern recognition receptors(PRRs)include a variety of recep-tots,in which toll-like receptors(TLRs)and dendritic cell-associated C-type lectin-1(Dectin-1),are thought to be involved in the host defense against fungi invasion.Activated TLRs and Dectin-1 will trigger immune response to release variety of cytokines and chemokines,and to induee the cellular processes of fun-gal binding,uptaking and final killing.The signal transduction pathways of TLRs and Dectin-1,their intera-cion and their immune functions against flungi infection has become a hot field of research.
