中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2008年
9期
547-549
,共3页
SEN病毒%肝炎,病毒性,人%血浆置换%聚合酶链反应
SEN病毒%肝炎,病毒性,人%血漿置換%聚閤酶鏈反應
SEN병독%간염,병독성,인%혈장치환%취합매련반응
SEN virus%Hepatitis,viral,human%Plasma exchange%Polymerase chain reaction
目的 了解重型肝炎患者血浆置换前、后SEN病毒(SENV)感染情况及对肝功能的影响.方法 采用套式PCR对40例重型肝炎患者血浆置换前、后血清中SENVD亚型和H亚型进行检测,并检测血浆置换前、后血液生化改变,数据行t检验和配对X2检验.结果 40例重型肝炎患者血浆置换前、后SENV D亚型的检出率分别为27.5%(11/40)和42.5%(17/40),SENVH亚型为27.5%(11/40)和50.0%(20/40),差异均有统计学意义(X24.17,X27.11;均P<0.05).血浆置换后,SENV阳性患者的ALT为(164±75)U/L,明显高于阴性患者的(48±12)U/L,差异有统计学意义(t=3.13,P<0.05);但肝功能其他各项指标比较,差异无统计学意义.结论 SENV可经血浆置换方式传播,且重叠SENV感染可能会影响重型肝炎患者血浆置换后肝功能的恢复.
目的 瞭解重型肝炎患者血漿置換前、後SEN病毒(SENV)感染情況及對肝功能的影響.方法 採用套式PCR對40例重型肝炎患者血漿置換前、後血清中SENVD亞型和H亞型進行檢測,併檢測血漿置換前、後血液生化改變,數據行t檢驗和配對X2檢驗.結果 40例重型肝炎患者血漿置換前、後SENV D亞型的檢齣率分彆為27.5%(11/40)和42.5%(17/40),SENVH亞型為27.5%(11/40)和50.0%(20/40),差異均有統計學意義(X24.17,X27.11;均P<0.05).血漿置換後,SENV暘性患者的ALT為(164±75)U/L,明顯高于陰性患者的(48±12)U/L,差異有統計學意義(t=3.13,P<0.05);但肝功能其他各項指標比較,差異無統計學意義.結論 SENV可經血漿置換方式傳播,且重疊SENV感染可能會影響重型肝炎患者血漿置換後肝功能的恢複.
목적 료해중형간염환자혈장치환전、후SEN병독(SENV)감염정황급대간공능적영향.방법 채용투식PCR대40례중형간염환자혈장치환전、후혈청중SENVD아형화H아형진행검측,병검측혈장치환전、후혈액생화개변,수거행t검험화배대X2검험.결과 40례중형간염환자혈장치환전、후SENV D아형적검출솔분별위27.5%(11/40)화42.5%(17/40),SENVH아형위27.5%(11/40)화50.0%(20/40),차이균유통계학의의(X24.17,X27.11;균P<0.05).혈장치환후,SENV양성환자적ALT위(164±75)U/L,명현고우음성환자적(48±12)U/L,차이유통계학의의(t=3.13,P<0.05);단간공능기타각항지표비교,차이무통계학의의.결론 SENV가경혈장치환방식전파,차중첩SENV감염가능회영향중형간염환자혈장치환후간공능적회복.
Objective To investigate the prevalence of SEN virus(SENV)infection in patients with chronic hepatitis gravis before and after plasma exchange,and its influences on liver function.Methods Two subtypes of SENV,SENV-D and SENV-H were detected in sera from 40 patients with chronic hepatitis gravis before and after plasma exchange.The changes of liver function were also tested before and after plasma exchange.Data analysis was done by t test and ehi-square test.Results Among 40 patients with chronic hepatitis gravis,SENV-D positive rates before and after plasma exchange were 27.5%(11/40)and 42.5%(17/40),respectively,and SENV-H positive rates before and after plasma exchange were 27.5%(11/40)and 50.0%(20/40),respectively,which were all significantly different(X2=4.17,X2=7.11,both P<0.05)between before plasma exchange and after plasma exchange.And after the treatment of plasma exchange,serum alanine aminotransferase(ALT)level was(164±75)U/L in SENV positive patients,which was significantly higher than that in SENV negative patients[(48±12)U/L,t=3.13,P<0.05].But there were no significant differences of other liver function indexes between SENV positive and negative groups.Condusions SENV can be transmitted via plasma exchange.SENV coinfection may influence the restoration of liver function in patients with chronic hepatitis gravia after the treatment of plasma exchange.
