国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
5期
16-17,19
,共3页
杨铭哲%林昭宇%梁云海%林育华%李冰
楊銘哲%林昭宇%樑雲海%林育華%李冰
양명철%림소우%량운해%림육화%리빙
血管紧张素转化酶%基因多态性%抑郁症
血管緊張素轉化酶%基因多態性%抑鬱癥
혈관긴장소전화매%기인다태성%억욱증
Epression%Angiotensin-converting enzyme%Polymerase chain reaction
目的 探讨单相抑郁症、双相抑郁症患者血管紧张素转化酶(ACE)基因第16内含子中287bp插入/缺失(I/D)多态的分布,以及ACE基因多态与抑郁症的关联性.方法 以100例抑郁症患者和100例正常对照组为对象进行病例对照研究,采用PCR检测ACE基因I/D多态性.结果 该多态位点的基因型在抑郁症组和正常对照组之间总体分布差异无显著性(P>0.05),两组间等位基因差异无显著性(P>0.05).结论 ACE基因I/D多态性与抑郁症不存在关联.
目的 探討單相抑鬱癥、雙相抑鬱癥患者血管緊張素轉化酶(ACE)基因第16內含子中287bp插入/缺失(I/D)多態的分佈,以及ACE基因多態與抑鬱癥的關聯性.方法 以100例抑鬱癥患者和100例正常對照組為對象進行病例對照研究,採用PCR檢測ACE基因I/D多態性.結果 該多態位點的基因型在抑鬱癥組和正常對照組之間總體分佈差異無顯著性(P>0.05),兩組間等位基因差異無顯著性(P>0.05).結論 ACE基因I/D多態性與抑鬱癥不存在關聯.
목적 탐토단상억욱증、쌍상억욱증환자혈관긴장소전화매(ACE)기인제16내함자중287bp삽입/결실(I/D)다태적분포,이급ACE기인다태여억욱증적관련성.방법 이100례억욱증환자화100례정상대조조위대상진행병례대조연구,채용PCR검측ACE기인I/D다태성.결과 해다태위점적기인형재억욱증조화정상대조조지간총체분포차이무현저성(P>0.05),량조간등위기인차이무현저성(P>0.05).결론 ACE기인I/D다태성여억욱증불존재관련.
Objective To explore the polymorphism about the Insertion/ deletion (I/D)for 287 Base pairs of the 16th intron in the gene of Angiotensin-converting enzyme in the patients of major depression and depression in biplor disorder, and the relationship between the polymorphism about the gene of Angiotensin-converting enzyme and depression. Methods Take 100 patients of depression and 100 Normal controls to conduct a control study, use Polymerase chain reaction to detect the polymorphism about the Insertion/ deletion(I/D)in gene of Angiotensin-converting enzyme. Results The overall distribution of the genotype of this polymorphic loci between depression group and normal controls has no significant difference(P>0.05),the allele between two group has no significant difference(P>0.05),Conclusion The polymorphism about Insertion/ deletion (I/D) in the gene of Angiotensin-converting enzyme has no relationship with depression.