中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2009年
10期
888-890
,共3页
汪卫华%赵汉清%汪广剑%宋梓祥%阎同军%蔡占魁%刘丽%薛蕴庄%钟爱芳%汪莉
汪衛華%趙漢清%汪廣劍%宋梓祥%閻同軍%蔡佔魁%劉麗%薛蘊莊%鐘愛芳%汪莉
왕위화%조한청%왕엄검%송재상%염동군%채점괴%류려%설온장%종애방%왕리
精神分裂症%抑郁症%瘦素%胆固醇%首次发病
精神分裂癥%抑鬱癥%瘦素%膽固醇%首次髮病
정신분렬증%억욱증%수소%담고순%수차발병
Schizophrenia%Depression%Leptin%Cholesterol%First-episode
目的 比较精神分裂症、抑郁症患者血浆瘦素及总胆固醇水平.方法 48例首发精神分裂症患者,用简明精神病评定量表(BPRS)、阳性和阴性症状量表(Positive and Negative Syndrome scale,PANSS)量表评定,45例首发抑郁症用汉密顿抑郁量表(HAMD-24)进行评定,32例体检职工为对照组,所有人组对象服药前测定体质量指数、血浆瘦素和总胆固醇.结果 (1)正常对照组[(4.8±0.9)mmol/L]总胆固醇均高于抑郁症组[(3.7±1.0)mmol/L]及精神分裂症组[(3.4±0.9)mmol/L;P＜0.05～0.01],而抑郁症组与精神分裂症组之间的差异无显著性(P＞0.05);正常对照组血浆瘦索[(13.4±6.7)g/L]高于抑郁症组[(9.6±4.2)g/L]及精神分裂症组[(5.8±3.4)g/L;P＜0.05～0.01],抑郁症组高于精神分裂症组(P＜0.05).(2)3组的血浆瘦素及总胆固醇均与BMI呈正相关(r=0.48～0.63;P＜0.01);精神分裂症组的血浆瘦素和总胆固醇与PANSS阳性分、BPRS分均呈显著负相关(r=-0.38～-0.50;均P＜0.01);抑郁症组的血浆瘦素、总胆固醇与HAMD分呈显著负相关(r=-0.37～-0.41;P＜0.05～0.01).结论 精神分裂症和抑郁症患者的血浆瘦素及总胆固醇水平的降低独立于药物治疗和BMI改变之外,其在精神障碍中的重要病理生理学机制值得进一步深入探讨.
目的 比較精神分裂癥、抑鬱癥患者血漿瘦素及總膽固醇水平.方法 48例首髮精神分裂癥患者,用簡明精神病評定量錶(BPRS)、暘性和陰性癥狀量錶(Positive and Negative Syndrome scale,PANSS)量錶評定,45例首髮抑鬱癥用漢密頓抑鬱量錶(HAMD-24)進行評定,32例體檢職工為對照組,所有人組對象服藥前測定體質量指數、血漿瘦素和總膽固醇.結果 (1)正常對照組[(4.8±0.9)mmol/L]總膽固醇均高于抑鬱癥組[(3.7±1.0)mmol/L]及精神分裂癥組[(3.4±0.9)mmol/L;P＜0.05～0.01],而抑鬱癥組與精神分裂癥組之間的差異無顯著性(P＞0.05);正常對照組血漿瘦索[(13.4±6.7)g/L]高于抑鬱癥組[(9.6±4.2)g/L]及精神分裂癥組[(5.8±3.4)g/L;P＜0.05～0.01],抑鬱癥組高于精神分裂癥組(P＜0.05).(2)3組的血漿瘦素及總膽固醇均與BMI呈正相關(r=0.48～0.63;P＜0.01);精神分裂癥組的血漿瘦素和總膽固醇與PANSS暘性分、BPRS分均呈顯著負相關(r=-0.38～-0.50;均P＜0.01);抑鬱癥組的血漿瘦素、總膽固醇與HAMD分呈顯著負相關(r=-0.37～-0.41;P＜0.05～0.01).結論 精神分裂癥和抑鬱癥患者的血漿瘦素及總膽固醇水平的降低獨立于藥物治療和BMI改變之外,其在精神障礙中的重要病理生理學機製值得進一步深入探討.
목적 비교정신분렬증、억욱증환자혈장수소급총담고순수평.방법 48례수발정신분렬증환자,용간명정신병평정량표(BPRS)、양성화음성증상량표(Positive and Negative Syndrome scale,PANSS)량표평정,45례수발억욱증용한밀돈억욱량표(HAMD-24)진행평정,32례체검직공위대조조,소유인조대상복약전측정체질량지수、혈장수소화총담고순.결과 (1)정상대조조[(4.8±0.9)mmol/L]총담고순균고우억욱증조[(3.7±1.0)mmol/L]급정신분렬증조[(3.4±0.9)mmol/L;P＜0.05～0.01],이억욱증조여정신분렬증조지간적차이무현저성(P＞0.05);정상대조조혈장수색[(13.4±6.7)g/L]고우억욱증조[(9.6±4.2)g/L]급정신분렬증조[(5.8±3.4)g/L;P＜0.05～0.01],억욱증조고우정신분렬증조(P＜0.05).(2)3조적혈장수소급총담고순균여BMI정정상관(r=0.48～0.63;P＜0.01);정신분렬증조적혈장수소화총담고순여PANSS양성분、BPRS분균정현저부상관(r=-0.38～-0.50;균P＜0.01);억욱증조적혈장수소、총담고순여HAMD분정현저부상관(r=-0.37～-0.41;P＜0.05～0.01).결론 정신분렬증화억욱증환자적혈장수소급총담고순수평적강저독립우약물치료화BMI개변지외,기재정신장애중적중요병리생이학궤제치득진일보심입탐토.
Objective To investigate the level of plasma ieptin and total cholesterol of first-episode schizophrenic and depressive patients.Methods 48 first-episode schizophrenic patients were assessed by Brief Psychiatric Rating Scale(BPRS),Positive and Negative Syndrome Scale (PANSS),45 depressive patients were assessed by Hamilton Depression Scale(HAMD-24) ,and 32 individuals who took part in health examination were selected as health control group.Body mass index(BMI) ,plasma leptin and total cholesterol were measured beforepressive group [(3.7±1.0) mmoL/L] and schizophrenic group [(3.4±0.9) mmoL/L] (P ＜ 0.05 ～ 0.01),but there was no significant difference between depressive group and schizophrenic group(P＞ 0.05) ; the plasma leptin of health control group[(13.4±6.7) g/L] was higher than depressive group [(9.6±4.2) g/L] and schizophrenic group[(5.8±3.4) g/L] (P ＜ 0.05～ 0.01),and schizophrenic group was obviously higher than depresBMI(r=0.48～0.63,P＜0.01) ; the plasma leptin and total cholesterol of the schizophrenic group were negatively correlated with PANSS positive score,PANSS score(r=-0.38～ -0.50,P＜ 0.01) ; the plasma leptin and total cholesterol of the depressive group were negatively correlated with HAMD score(r=-0.37 ～ -0.41,P＜0.05～0.01).Conclusion The degradation of plasma leptin and total cholesterol of the schizophrenic and depressive patients were independent of medication and BMl,and the pathophysiologic mechanism in mental disorders deserve further research.
