CAJ | 학술논문

目的探讨脑电非线性分析在急性一氧化碳中毒(ACMP)疗效评估中的价值. 方法选取川北医学院附属医院神经内科自2010年11月至2011年3月收治的ACMP患者21例,分别于入院时、入院治疗2周及入院治疗4周时采集脑电信号,将3个时间点获取的脑电信号行非线性分析(D2、Cx、ApEn、C-ApEn、Dm、PD2、LE和KE)并分别与21例正常对照者比较. 结果 ACMP组D2、Cx、ApEn、C -ApEn、Dm值随治疗时间的延长有逐步增高的趋势,而PD2、LE和KE值与治疗周期无相关性.入院时ACMP组D2、Cx、ApEn、C-ApEn、Dm平均值与对照组比较差异具有统计学意义(P＜0.05)；入院治疗2周及入院治疗4周的ACMP组脑电非线性参数(LE、PD2、D2、Dm、Cx、ApEn及C-ApEn)平均值与对照组相比差异均无统计学意义(P＞0.05). 结论脑电非线性参数(D2、DM、Cx、ApEn、C-ApEn)在ACMP治疗初期能较同步客观地反映脑功能的恢复情况,具有一定的评估疗效价值.
목적 탐토뇌전비선성분석재급성일양화탄중독(ACMP)료효평고중적개치. 방법 선취천북의학원부속의원신경내과자2010년11월지2011년3월수치적ACMP환자21례,분별우입원시、입원치료2주급입원치료4주시채집뇌전신호,장3개시간점획취적뇌전신호행비선성분석(D2、Cx、ApEn、C-ApEn、Dm、PD2、LE화KE)병분별여21례정상대조자비교. 결과 ACMP조D2、Cx、ApEn、C -ApEn、Dm치수치료시간적연장유축보증고적추세,이PD2、LE화KE치여치료주기무상관성.입원시ACMP조D2、Cx、ApEn、C-ApEn、Dm평균치여대조조비교차이구유통계학의의(P＜0.05)；입원치료2주급입원치료4주적ACMP조뇌전비선성삼수(LE、PD2、D2、Dm、Cx、ApEn급C-ApEn)평균치여대조조상비차이균무통계학의의(P＞0.05). 결론 뇌전비선성삼수(D2、DM、Cx、ApEn、C-ApEn)재ACMP치료초기능교동보객관지반영뇌공능적회복정황,구유일정적평고료효개치.
Objective To investigate the value of electroencephalogram (EEG) nonlinear parameters in assessing the therapeutic efficacy in patients with acute carbon monoxide poisoning (ACMP). Methods Twenty-one patients diagnosed with ACMP in our department from November 2010 to March 2011 and 21 healthy volunteers were enrolled in this study.The EEG nonlinear parameters were obtained fi om the patients for analysis on the day of admission, at 2 and 4 weeks post-treatment,respectively,including approximate entropy (ApEn),cross-approximate entropy (C-ApEn),correlation dimension (D2),point wise correlation dimension (PD2),mutual dimension (Dm),Lyapunov exponent (LE),Kolmogorov entropy (KE) and Complexity (Cx).The EEG nonlinear parameters of the patients were compared with those of the healthy volunteers. Results The mean values of D2, Cx,ApEn,C-ApEn and Dm were found to gradually increase with the duration of therapy, whereas the values of PD2,LE and KE had no association with the therapy.On the day of admission,the mean values of D2,Cx,ApEn, C-ApEn and Dm for ACMP patients were significantly different from those of the healthy volunteers (P＜0.05),but at 2 and 4 weeks post-therapy,the mean values ofLE,PD2,D2,Dm,Cx,ApEn and C-ApEn of the ACMP patients were not significantly different from those of the healthy volunteers (P＞0.05). Conclusion Since EEG nonlinear parameters (D2,DM,Cx,ApEn,C-ApEn) can objectively reflect the status of brain functional recovery in ACMP patients at an early treatment stage,they can serve as practical measures in the treatment of ACMP.