中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2008年
10期
33-34
,共2页
心力衰竭%曲美他嗪%脑钠肽
心力衰竭%麯美他嗪%腦鈉肽
심력쇠갈%곡미타진%뇌납태
Heart failure%Trimetazidine%Brain natriuretic peptide
目的 观察曲美他嗪对慢性心力衰竭患者血浆脑钠肽(BNP)水平的影响和BNP在心力衰竭(心衰)判断中的临床价值.方法 选择慢性心衰患者68例,随机分为对照组和曲美他嗪组.对照组,应用常规抗心衰药物治疗.曲美他嗪组在常规抗心衰治疗基础上加用曲美他嗪.两组疗程均为4周,观察治疗前后两组NYHA分级、心功能、BNP等指标的变化.结果 经治疗后曲美他嗪组心衰疗效优于常规抗心衰组,血浆BNP下降率大于常规抗心衰组,曲美他嗪组左室射血分数较治疗前明显增加,也明显高于常规抗心衰组治疗后的水平.结论 曲美他嗪能降低血浆BNP水平,改善CHF病人的心功能,BNP可以作为临床判断慢性心力衰竭严重程度及评价治疗效果的生化指标.心力衰竭诊断、治疗和预后评估的的指标.
目的 觀察麯美他嗪對慢性心力衰竭患者血漿腦鈉肽(BNP)水平的影響和BNP在心力衰竭(心衰)判斷中的臨床價值.方法 選擇慢性心衰患者68例,隨機分為對照組和麯美他嗪組.對照組,應用常規抗心衰藥物治療.麯美他嗪組在常規抗心衰治療基礎上加用麯美他嗪.兩組療程均為4週,觀察治療前後兩組NYHA分級、心功能、BNP等指標的變化.結果 經治療後麯美他嗪組心衰療效優于常規抗心衰組,血漿BNP下降率大于常規抗心衰組,麯美他嗪組左室射血分數較治療前明顯增加,也明顯高于常規抗心衰組治療後的水平.結論 麯美他嗪能降低血漿BNP水平,改善CHF病人的心功能,BNP可以作為臨床判斷慢性心力衰竭嚴重程度及評價治療效果的生化指標.心力衰竭診斷、治療和預後評估的的指標.
목적 관찰곡미타진대만성심력쇠갈환자혈장뇌납태(BNP)수평적영향화BNP재심력쇠갈(심쇠)판단중적림상개치.방법 선택만성심쇠환자68례,수궤분위대조조화곡미타진조.대조조,응용상규항심쇠약물치료.곡미타진조재상규항심쇠치료기출상가용곡미타진.량조료정균위4주,관찰치료전후량조NYHA분급、심공능、BNP등지표적변화.결과 경치료후곡미타진조심쇠료효우우상규항심쇠조,혈장BNP하강솔대우상규항심쇠조,곡미타진조좌실사혈분수교치료전명현증가,야명현고우상규항심쇠조치료후적수평.결론 곡미타진능강저혈장BNP수평,개선CHF병인적심공능,BNP가이작위림상판단만성심력쇠갈엄중정도급평개치료효과적생화지표.심력쇠갈진단、치료화예후평고적적지표.
Objective To observe the effects of trimetazidine on changes of plasma brain natriuretic peptide(BNP)and the clinical value of BNP in the diagnosis of chronic heart failure(CHF).Methods Sixtyeight patients with CHF were randomly divided into trimetazidine group and the conventional group,patients in the trimetazidine group were given trimetazidine 20 mg,tid,for 4 weeks.NYHA functional class,plasma BN-Pand echocardiographic indices(LVEDD,LVMI,LVEF)were evaluated before and after 4 weeks'therapy.Results After 4 weeks therapy,compared with the patients in the conventional group,trimetazidine improve cardiac function and reduce the Ievel of plasma BNP significantly.Conclusion Trimetazidine might improve cardiac function and reduce the level of plasma BNP in CHF patients,and plasma BNP might serve as a good indicator for evaluation of CHF and therapy in CHF patients.
