CAJ | 학술논문

目的探讨直肠癌病人外周血NK细胞和T淋巴细胞亚群的变化及临床意义。方法分别应用同位素及流式细胞仪法检测26例正常人(无肿瘤)和35例直肠癌患者(包括术前术后)外周血NK细胞和T淋巴细胞亚群数目。结果 NK细胞，CD3，CD4，CD4/CD8比值在直肠癌组与对照组差异显著性(P<0.05)。直肠癌患者随Dudes分期增高而NK细胞，CD3，CD4，CD4/CD8比值逐渐下降，差异均有极显著性(P<0.01)。根治术和姑息性切除术后NK细胞CD3，CD4，CD4/CD8升高，CD8回落接近对照组。肿瘤未切除组术后NK细胞，CD3，CD4，CD4/CD8则进一步下降，差异有显著性(P<0.05)。结论直肠癌患者NK细胞等各项免疫指标大大降低，这种免疫紊乱状态在不同病情又有显著差别，根治术和姑息性切除术可明显改善病人的免疫状态。
목적탐토직장암병인외주혈NK세포화T림파세포아군적변화급림상의의。방법분별응용동위소급류식세포의법검측26례정상인(무종류)화35례직장암환자(포괄술전술후)외주혈NK세포화T림파세포아군수목。결과 NK세포，CD3，CD4，CD4/CD8비치재직장암조여대조조차이현저성(P<0.05)。직장암환자수Dudes분기증고이NK세포，CD3，CD4，CD4/CD8비치축점하강，차이균유겁현저성(P<0.01)。근치술화고식성절제술후NK세포CD3，CD4，CD4/CD8승고，CD8회락접근대조조。종류미절제조술후NK세포，CD3，CD4，CD4/CD8칙진일보하강，차이유현저성(P<0.05)。결론직장암환자NK세포등각항면역지표대대강저，저충면역문란상태재불동병정우유현저차별，근치술화고식성절제술가명현개선병인적면역상태。
Objective　To investigate the alteration and clinical significance of NK cell and T lymphocyte subpopulatien in patients with rectal carcinoma. Methods　 The numbers of NK cell and T lymphocyte in 26 healthy persons and 35 rectal carcinoma patients were detected by 3H-releasing method and FCM. Results　NK cell and CD3, CD4, CD4/CD8 were decreased significantly in patients with rectal carcinoma (P<0.05), which was positively correlated with Dukes staging (P<0.01), and was inereased after redical or palliative operation (P<0.05), but NK cell and CD3, CD4, CD4/CD8 were further decreased in patients with unresectable tumor after operation (P<0.05). Conclusions　The immunity of rectal patients was decreased with the development of the disease, and it will be improved after radical of palliative operation.