化学世界
化學世界
화학세계
CHEMICAL WORLD
2009年
10期
607-610
,共4页
2-氯苄基-N-琥珀酰亚胺基碳酸酯%合成%N-羟基琥珀酰亚胺
2-氯芐基-N-琥珀酰亞胺基碳痠酯%閤成%N-羥基琥珀酰亞胺
2-록변기-N-호박선아알기탄산지%합성%N-간기호박선아알
N-(2-chlorobenzyloxycarbonyldioxy)-succinimide%synthesis%N-hydroxy succinimide
以2-氯苄醇和三氯甲基碳酸双酯为起始原料,以二氯乙烷为溶剂,合成了氯甲酸2-氯苄酯,并和N-羟基琥珀酰亚胺反应制备得到肽类保护剂2-氯苄基-N-琥珀酰亚胺基碳酸酯.对反应条件进行了优化,两步反应的总收率接近50%,所得产品经~1H NMR确证.
以2-氯芐醇和三氯甲基碳痠雙酯為起始原料,以二氯乙烷為溶劑,閤成瞭氯甲痠2-氯芐酯,併和N-羥基琥珀酰亞胺反應製備得到肽類保護劑2-氯芐基-N-琥珀酰亞胺基碳痠酯.對反應條件進行瞭優化,兩步反應的總收率接近50%,所得產品經~1H NMR確證.
이2-록변순화삼록갑기탄산쌍지위기시원료,이이록을완위용제,합성료록갑산2-록변지,병화N-간기호박선아알반응제비득도태류보호제2-록변기-N-호박선아알기탄산지.대반응조건진행료우화,량보반응적총수솔접근50%,소득산품경~1H NMR학증.
Starting from 2-chlorobenzyl alcohol and bis (trichloromethyl) carbonate, 2-chlorobenzyl chloroformate was synthesized with dichloroethane as the solvent, then via reaction with N-hydroxysuccinimide,
the important peptide protecting reagent, N-(2-chlorobenzyloxycarbonyloxy)-succinimide was successfully obtained. The optimum reaction conditions of the two steps were found and the total yield reached 50%. The product was confirmed by ~1H NMR.