国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2011年
1期
57-60,64
,共5页
Th17细胞%IL-17%IL-23-Th17轴%IL-25%气道变应性疾病
Th17細胞%IL-17%IL-23-Th17軸%IL-25%氣道變應性疾病
Th17세포%IL-17%IL-23-Th17축%IL-25%기도변응성질병
Th17 cell%IL-17%IL-23-Th17 axis%IL-25%Airway allergic disease
气道变应性疾病传统上认为是以Th2型免疫应答占优势的Th1/Th2细胞功能失衡所致.近年来,大量研究证实Th17细胞在气道变应性炎症中发挥重要作用,使人们对气道变应性疾病有了崭新的认识.IL-17A能促进中性粒细胞的募集、活化,促进炎症反应;IL-23-Th1轴不仅能诱导中性粒细胞性气道炎症,还能正调节嗜酸性粒细胞性气道炎症,IL-25(IL-17E)对气道变应性炎症有放大效应,因而Th17细胞及其相关细胞因子或许能为气道变应性疾病的治疗提供新的思路.
氣道變應性疾病傳統上認為是以Th2型免疫應答佔優勢的Th1/Th2細胞功能失衡所緻.近年來,大量研究證實Th17細胞在氣道變應性炎癥中髮揮重要作用,使人們對氣道變應性疾病有瞭嶄新的認識.IL-17A能促進中性粒細胞的募集、活化,促進炎癥反應;IL-23-Th1軸不僅能誘導中性粒細胞性氣道炎癥,還能正調節嗜痠性粒細胞性氣道炎癥,IL-25(IL-17E)對氣道變應性炎癥有放大效應,因而Th17細胞及其相關細胞因子或許能為氣道變應性疾病的治療提供新的思路.
기도변응성질병전통상인위시이Th2형면역응답점우세적Th1/Th2세포공능실형소치.근년래,대량연구증실Th17세포재기도변응성염증중발휘중요작용,사인문대기도변응성질병유료참신적인식.IL-17A능촉진중성립세포적모집、활화,촉진염증반응;IL-23-Th1축불부능유도중성립세포성기도염증,환능정조절기산성립세포성기도염증,IL-25(IL-17E)대기도변응성염증유방대효응,인이Th17세포급기상관세포인자혹허능위기도변응성질병적치료제공신적사로.
Airway allergic diseases have classically been considered as the results of dysregulation of Th1/Th2 paradigm, dominated by Th2 cells. Recently,researches demonstrate that Th17 cells play crucial roles in the development of airway allergic inflammation, which provides new insight into the pathogenesis of airway allergic diseases. IL-17A can promote neutrophil recruitment and enhance airway inflammation; IL-23-Th17 axis not only induces neutrophilic airway inflammation, but also up-regulate eosinophilic airway inflammation;IL-25(IL-17E) may amplify the Th2-mediated airway allergic inflammation. Thl7 cells and some related cytokines may provide new strategy for the treatment of airway allergic diseases.
