CAJ | 학술논문

目的观察新疆哈萨克族(哈族)、汉族高血压病(HT)患者血浆抵抗素水平及其与胰岛素抵抗(IR)、血糖、血脂、血压及肥胖指标的关系.方法选取新疆哈族人127例及汉族人131例作为研究对象.根据血压水平,分为哈族HT组、哈族对照组、汉族HT组、汉族对照组.均测量血压、身高、体重、腰围(WC)及臀围,抽取空腹静脉血,检测血浆抵抗素、胰岛素(FINS)、血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(Apo-A1)、栽脂蛋白B(Apo-B).计算体重指数(BMI)、腰臀比(WHR)、体内脂肪百分比(BF%)、HOMA-胰岛素抵抗指数(HOMA-IR)等进行比较.结果哈、汉HT组血浆抵抗素水平均明显高于相应的对照组(P<0.01);哈、汉HT组间或哈、汉对照组间血浆抵抗素水平差异无统计学意义(P>0.05);在哈、汉HT组,抵抗素均与年龄、SBP、WC、BMI、WHR、BF%、FPG、FINS、HOMA-IR、TG呈正相关(哈HT组r=0.492,0.296,0.281,0.648,0.263,0.515,0.742,0.759,0.797,0.595;汉HT组r=0.417,0.275,0.391,0.483,0.278,0.318,0.453,0.560,0.641,0.310;P<0.05);调整年龄、血糖、血脂、肥胖等指标后,各组中抵抗素仍与FINS、HOMA-IR呈正相关(哈HT组r=0.432,0.410;哈对照组r=0.327,0.305;汉HT组r=0.426,0.425;汉对照组r=0.377,0.392;P<0.05),与SBP、DBP无相关(P>0.05);在哈族FIT组,HOMA-IR、FPG和BMI是影响血浆抵抗素水平的独立因素;在汉族HT组,HOMA-IR、FPG和BF%是影响血浆抵抗素水平的独立因素.结论哈、汉HT患者血浆抵抗素水平升高,其血浆抵抗素与肥胖、血糖及IR关系密切.与血压可能存在间接关系.
목적 관찰신강합살극족(합족)、한족고혈압병(HT)환자혈장저항소수평급기여이도소저항(IR)、혈당、혈지、혈압급비반지표적관계.방법 선취신강합족인127례급한족인131례작위연구대상.근거혈압수평,분위합족HT조、합족대조조、한족HT조、한족대조조.균측량혈압、신고、체중、요위(WC)급둔위,추취공복정맥혈,검측혈장저항소、이도소(FINS)、혈당(FPG)、총담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、재지단백A1(Apo-A1)、재지단백B(Apo-B).계산체중지수(BMI)、요둔비(WHR)、체내지방백분비(BF%)、HOMA-이도소저항지수(HOMA-IR)등진행비교.결과 합、한HT조혈장저항소수평균명현고우상응적대조조(P<0.01);합、한HT조간혹합、한대조조간혈장저항소수평차이무통계학의의(P>0.05);재합、한HT조,저항소균여년령、SBP、WC、BMI、WHR、BF%、FPG、FINS、HOMA-IR、TG정정상관(합HT조r=0.492,0.296,0.281,0.648,0.263,0.515,0.742,0.759,0.797,0.595;한HT조r=0.417,0.275,0.391,0.483,0.278,0.318,0.453,0.560,0.641,0.310;P<0.05);조정년령、혈당、혈지、비반등지표후,각조중저항소잉여FINS、HOMA-IR정정상관(합HT조r=0.432,0.410;합대조조r=0.327,0.305;한HT조r=0.426,0.425;한대조조r=0.377,0.392;P<0.05),여SBP、DBP무상관(P>0.05);재합족FIT조,HOMA-IR、FPG화BMI시영향혈장저항소수평적독립인소;재한족HT조,HOMA-IR、FPG화BF%시영향혈장저항소수평적독립인소.결론 합、한HT환자혈장저항소수평승고,기혈장저항소여비반、혈당급IR관계밀절.여혈압가능존재간접관계.
Objective To observe plasma resistin levels in patients with essential hypertension (HT) of Xinjiang Kazakans and Han nationalities, and explore its association with insulin resistance (IR), blood glucose, blood lipids, blood pressure and obesity. Methods Total 127 Kazakan cases and 131 Han cases were selected as the subjects. According to their blood pressure, they were divided into HT group of Kazakans, control group of Kazakans, HT group of Hans and control group of Hans. Blood pressure, height, weight, waist circum-ference (WC) and hip were measured. Plasma resistin, fasting insulin(FINS), fasting plasma glucose (FPG), total cholesterol (TC), tri-glyceride (TG), high-density lipoprotein cholesterol ( HDL-C), low-density lipoprotein cholesterol ( LDL-C), apoprotein-A1( Apo-A1)and apoprotein-B(Apo-B) were determined. Body mass index (BMI), waist-hip ratio ( WHR), body fat percentage ( BF% )and homeostasis model assessment of insulin resistance index ( HOMA-IR) were calculated. Results Plasma resistin levels in the HT groups of Kazakans and Hans were significantly higher than those in their control groups ( P<0.01 ). There were no significant difference in the comparison of plasma resistin levels in HT groups or control groups between Kazakans and Hans ( P>0.05). Plasma resistin was posi-tively and significandy correlated with age, systolic blood pressure (SBP), WC, BMI, WHR, BF%, FlaG, FINS, HOMA-IR, TG in HT groups of Kazakans and Hans ( HT group of Kazakans, r=0.492,0.296,0.281,0.648,0.263,0.515,0.742,0.759,0.797,0.595; HT group of Hans, r=0.417,0.275,0.391,0.483,0.278,0.318,0.453,0.560,0.641,0.310; P<0.05). After the influential factors such as age, blood glucose, blood lipids and obesity were adjusted, plasma resistin level in four groups were still positively and significantly corre-lated with FINS and HOMA-IR ( HT group of Kazakans, r=0.432,0.410 ; control group of Kazakans, r=0.327,0.305 ; HT group of Hans, r=0.426,0.425 ; control group of Hans, r=0.377,0.392 ; P<0.05), but not correlated with SBP or DBP( P>0.05 ). HOMA-IR, FPG and BMI were independent factors for plasma resistin level in HT group of Kazakans, while HOMA-IR, FlaG and BF% were inde-pendent factors for plasma resistin level in HT group of Hans. Conclusion Plasma resistin level was increased in patients with HT of Kaza-karts and Hans. Close correlations between resistin and obesity, blood glucose and IR were found, and there may be indirect correlation be-tween resistin and blood pressure.