CAJ | 학술논문

目的探讨COX-2和VEGF在非霍奇金淋巴瘤(NHL)中的表达及临床意义.方法采用免疫组化SP法检测COX-2和VEGF在42例NHL和20例良性淋巴结病变组织中的表达.结果 COX-2和VEGF在NHL中的阳性表达率分别为45.24%(19/42)和73.81%(31/42).COX-2和VEGF在NHL的表达呈正相关(x2=4.63,P＜0.05).COX-2的表达与NHL的临床分期和病理组织学类型具有相关性,Ⅲ/Ⅳ期NHL患者COX-2蛋白的表达明显高于Ⅰ/Ⅱ期患者(x2=5.43,P＜0.05),侵袭性NHL患者COX-2蛋白的表达高于惰性组(x2=5.54,P＜0.05),而与患者性别、年龄、全身症状、IPI无相关性.VEGF的表达与淋巴瘤侵袭性及全身症状、IPI显著相关(x2=8.98,8.89,6.43,P＜0.05),而与患者的年龄、性别、临床分期均无相关性.结论 COX-2、VEGF可能参与NHL的发生、发展过程,COX-2可能通过上调VEGF促进NHL组织的血管新生.选择性COX-2抑制剂可望成为NHL治疗的新靶点.
목적 탐토COX-2화VEGF재비곽기금림파류(NHL)중적표체급림상의의.방법 채용면역조화SP법검측COX-2화VEGF재42례NHL화20례량성림파결병변조직중적표체.결과 COX-2화VEGF재NHL중적양성표체솔분별위45.24%(19/42)화73.81%(31/42).COX-2화VEGF재NHL적표체정정상관(x2=4.63,P＜0.05).COX-2적표체여NHL적림상분기화병리조직학류형구유상관성,Ⅲ/Ⅳ기NHL환자COX-2단백적표체명현고우Ⅰ/Ⅱ기환자(x2=5.43,P＜0.05),침습성NHL환자COX-2단백적표체고우타성조(x2=5.54,P＜0.05),이여환자성별、년령、전신증상、IPI무상관성.VEGF적표체여림파류침습성급전신증상、IPI현저상관(x2=8.98,8.89,6.43,P＜0.05),이여환자적년령、성별、림상분기균무상관성.결론 COX-2、VEGF가능삼여NHL적발생、발전과정,COX-2가능통과상조VEGF촉진NHL조직적혈관신생.선택성COX-2억제제가망성위NHL치료적신파점.
Objectiye To explore the expression of COX-2 and VEGF and its clinical significance in non-Hodgkin lymphoma (NHL). Methods The expression of COX-2 and VEGF were detected by immunohistochemistry in 42 cases of NHL and 20 cases of lymph node with benign pathological change. Results The positive rate of COX-2 and VEGF was 45.24% and 73.81% in NHL respectively. The expression rate of VEGF was positively correlated with that of COX-2 in tissues of NHL ( x2 = 4. 63, P ＜ 0. 05).The expression of COX-2 was related to clinical stage and histopathologic grade of NHL ( x2 = 5.43, P ＜0. 05), but it had no association with gender, age, B symptoms, and IPI. The expression of VEGF was significantly related with aggression, B symptoms and IPI ( x2 =8. 979, 8. 893,6. 434, P ＜0. 05), but it had no association with age, gender and clinical stages. Conclusion COX-2 and VEGF may be involved in NHL tumorgenesis, and COX-2 may accelerate angiogenesis by increasing VEGF expression. Specific COX-2 inhibitors may be a novel therapeutic approach for NHL.