中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2009年
2期
128-130
,共3页
陈飞鹏%黄金桔%邬勇坚%阳隽
陳飛鵬%黃金桔%鄔勇堅%暘雋
진비붕%황금길%오용견%양준
解整合素-金属蛋白酶%非小细胞肺癌%EUSA
解整閤素-金屬蛋白酶%非小細胞肺癌%EUSA
해정합소-금속단백매%비소세포폐암%EUSA
A distintegrin and metalloproteases%Non-small cell lung cancer%ELISA
目的 探讨解整合素-金属蛋白酶8(ADAM8)对非小细胞肺癌患者(NSCLC)的诊断价值.方法 应用ELISA方法 检测62例NSCLC患者、27例良性肺病患者和32例健康体检者血清中的ADAM8蛋白表达水平.结果 NSCLC组血清ADAM8水平[(456.88±143.87)ng/L]高于良性肺病组[(271.63±74.20)ng/L]和正常对照组[(253.09±72.15)ng/L],差异均有统计学意义(P均<0.01),良性肺病组AD-AM8表达水平比正常对照组略高,但差异无统计学意义(P0.05);ADAM8在腺癌患者中表达水平与鳞癌相比差异无统计学意义[(462.54±161.387)ng/L与(449.04±118.03)ng/L,P0.05],Ⅲ、Ⅳ期NSCLC患者血清中ADAM8的水平[(498.80±151.80)ng/L]高于Ⅰ、Ⅱ期患者[(385.80±95.85)ng/L],差异有统计学意义(P<0.01);检测ADAM8对NSCLC的诊断敏感性为77.4%,特异性为90.6%.结论 ADAM8在NSCLC患者血清中过度表达,表明其与肺癌的发生和转移有着密切的关系,检测ADAM8对NSCLC的诊断有一定的辅助价值.
目的 探討解整閤素-金屬蛋白酶8(ADAM8)對非小細胞肺癌患者(NSCLC)的診斷價值.方法 應用ELISA方法 檢測62例NSCLC患者、27例良性肺病患者和32例健康體檢者血清中的ADAM8蛋白錶達水平.結果 NSCLC組血清ADAM8水平[(456.88±143.87)ng/L]高于良性肺病組[(271.63±74.20)ng/L]和正常對照組[(253.09±72.15)ng/L],差異均有統計學意義(P均<0.01),良性肺病組AD-AM8錶達水平比正常對照組略高,但差異無統計學意義(P0.05);ADAM8在腺癌患者中錶達水平與鱗癌相比差異無統計學意義[(462.54±161.387)ng/L與(449.04±118.03)ng/L,P0.05],Ⅲ、Ⅳ期NSCLC患者血清中ADAM8的水平[(498.80±151.80)ng/L]高于Ⅰ、Ⅱ期患者[(385.80±95.85)ng/L],差異有統計學意義(P<0.01);檢測ADAM8對NSCLC的診斷敏感性為77.4%,特異性為90.6%.結論 ADAM8在NSCLC患者血清中過度錶達,錶明其與肺癌的髮生和轉移有著密切的關繫,檢測ADAM8對NSCLC的診斷有一定的輔助價值.
목적 탐토해정합소-금속단백매8(ADAM8)대비소세포폐암환자(NSCLC)적진단개치.방법 응용ELISA방법 검측62례NSCLC환자、27례량성폐병환자화32례건강체검자혈청중적ADAM8단백표체수평.결과 NSCLC조혈청ADAM8수평[(456.88±143.87)ng/L]고우량성폐병조[(271.63±74.20)ng/L]화정상대조조[(253.09±72.15)ng/L],차이균유통계학의의(P균<0.01),량성폐병조AD-AM8표체수평비정상대조조략고,단차이무통계학의의(P0.05);ADAM8재선암환자중표체수평여린암상비차이무통계학의의[(462.54±161.387)ng/L여(449.04±118.03)ng/L,P0.05],Ⅲ、Ⅳ기NSCLC환자혈청중ADAM8적수평[(498.80±151.80)ng/L]고우Ⅰ、Ⅱ기환자[(385.80±95.85)ng/L],차이유통계학의의(P<0.01);검측ADAM8대NSCLC적진단민감성위77.4%,특이성위90.6%.결론 ADAM8재NSCLC환자혈청중과도표체,표명기여폐암적발생화전이유착밀절적관계,검측ADAM8대NSCLC적진단유일정적보조개치.
Objective To study the diagnostic values of a distintegrin and metalloproteases-8 (ADAMS) in non-small cell lung cancer(NSCLC).Methods The serum protein level of ADAM8 was assayed by ELISA in 62 NSCLC patients,27 lung benign lesions and 32 healthy people.Results The serum levels of ADAM8 of NSCLC [(456.88±143.87)ng/L] were higher than those with lung benign lesions[ (271.63±74.20) ng/L] and normal controls(253.09±72.15 ng/L) (P<0.01), but there was no significant difference between lung benign lesions and normal controls (P0.05).No significant difference was found between adenocarcinoma and squamous cell carcinoma in serum ADAM8 level,the serum levels of ADAM8 in NSCLC with stages Ⅲ-Ⅳ [ (498.80 ± 151.80) ng/L] were higher than those with stages Ⅰ -Ⅱ[(385.80±95.85) ng/L] (P <0.01 ).The diagnostic sensitivity of detection of ADAM8 for NSCLC was 77.4% and the specificity was 90.6%.Conclusion The overexpression of ADAM8 in serum of NSCLC patients indicates that ADAM8 is related with occurrence and metastasis of NSCLC;De-tection of ADAM8 could assist the diagnosis for NSCLC.
