CAJ | 학술논문

目的观察慢性汞中毒引起肾损伤的临床表现,研究新修订的GBZ 89-2007(职业性汞中毒诊断标准>的应用价值.方法对8例慢性职业性轻度汞中毒患者的临床表现、诊断、治疗及预后进行综合分析.结果 8例慢性轻度汞中毒患者主要的临床表现如尿汞增高、神经衰弱综合征、手指震颤,可伴舌、眼睑震颤和近端肾小管功能障碍如尿低相对分子质量蛋白含量增高等与现行<职业性汞中毒诊断标准>中轻度中毒的诊断指标相符,职业性慢性汞中毒引起的肾损伤以β2-微球蛋白含量的增加为主要表现,且与接触工龄间存在剂量-效应关系,驱汞治疗后可以逆转.结论新修订的GBZ 89-2007在临床诊断应用中具有实用价值,慢性汞中毒引起的肾损伤应引起临床医生的高度重视.
목적 관찰만성홍중독인기신손상적림상표현,연구신수정적GBZ 89-2007(직업성홍중독진단표준>적응용개치.방법 대8례만성직업성경도홍중독환자적림상표현、진단、치료급예후진행종합분석.결과 8례만성경도홍중독환자주요적림상표현여뇨홍증고、신경쇠약종합정、수지진전,가반설、안검진전화근단신소관공능장애여뇨저상대분자질량단백함량증고등여현행<직업성홍중독진단표준>중경도중독적진단지표상부,직업성만성홍중독인기적신손상이β2-미구단백함량적증가위주요표현,차여접촉공령간존재제량-효응관계,구홍치료후가이역전.결론 신수정적GBZ 89-2007재림상진단응용중구유실용개치,만성홍중독인기적신손상응인기림상의생적고도중시.
Objective To investigate the clinical manifestation of patients with renal injury induced by chronic mercury intoxication and the application of the diagnostic criteria of occupational mercury poisoning. Methods The clinical data of 8 patients with chronic occupational mercury intoxication were analysed and evaluated. Results All the observed clinical signs of chronic mercury intoxication correspond with the items of the diagnostic criteria of occupational mercury poisoning. The increasing β2-MG was one of the clinical manifestations of renal injury induced by chronical mercury intoxication. The renal injury obviously was dose-dependent and reversible. Conclusions The national diagnostic criteria of occupational mercury poisoning is practically valuable. The renal injury induced by chronic mercury intoxication should not be neglected.