CAJ | 학술논문

以可生物降解的明胶为载体,液体石蜡为油相,Span-80为乳化剂,选择正交设计优化空白明胶微球生产工艺,并考察其理化性质,采用乳化交联法制备二氟沙星肺靶向明胶微球.采用紫外可见分光光度计法,测定微球中二氟沙星的含量.结果表明,优选所制的二氟沙星肺靶向明胶微球形态圆整,表面光滑,平均粒径为8.33μm,粒径分布在5.0～25.0μm的微球达到95.71%,二氟沙星明胶微球包封率为62.43%.载药量为13.71%.采用动态分析法研究体外释药特性,二氟沙星明胶微球在12 h处药物释放量达到65%,24 h内药物释放量达到71%.制备工艺稳定可行,所得二氟沙星明胶微球具有良好的缓释效果.
이가생물강해적명효위재체,액체석사위유상,Span-80위유화제,선택정교설계우화공백명효미구생산공예,병고찰기이화성질,채용유화교련법제비이불사성폐파향명효미구.채용자외가견분광광도계법,측정미구중이불사성적함량.결과표명,우선소제적이불사성폐파향명효미구형태원정,표면광활,평균립경위8.33μm,립경분포재5.0～25.0μm적미구체도95.71%,이불사성명효미구포봉솔위62.43%.재약량위13.71%.채용동태분석법연구체외석약특성,이불사성명효미구재12 h처약물석방량체도65%,24 h내약물석방량체도71%.제비공예은정가행,소득이불사성명효미구구유량호적완석효과.
The preparation technology was optimized by odhogonal experimental designed with biodegradable gelatin as the carrier,liquid paraffin as the oilphase,span-80 as the emulsifier,and Difloxacin loaded gelatin microsphere for lung targetting was prepared by the emulsion crosslinking method.Quantitative determination of Difloxacin was carded on by the method of UV spectrephotometry. and the optimal Difloxacin loaded gelatin microsphere was global with smooth surface,The arithmetic mean diameter of microsphere was 8.33 μm with 95.71%of microsphere which are ranging from 5.0 to 25.0 μm,total 62.43% for the encapsulation efficiency,and 13.71%for the drug loading,The release test in vitroshowed that 65% of Difloxacin could release from gelatin micresphere in 12 h and 71% in 24 h with dynamic analysis.The preparation technology is good and stable,and the obtained microsphere can control the release of Difioxacin.