CAJ | 학술논문

近年来全基因组关联研究在世界范围内发展迅猛,研究者应用全基因组关联研究策略发现了一系列疾病的相关基因或变异,将疾病的基因组研究推向一个新的阶段.冠心病是一种由环境因素和遗传因素共同作用导致的复杂疾病,且是世界范围内死亡和致残的首要原因之一,世界各地的研究者应用此策略发现了候选基因关联研究未曾发现的多个冠心病相关易感区域.文章对近年来世界范围内针对冠心病的全基因组关联研究取得的重要进展进行简要总结,然后就现阶段全基因组关联研究所面临的挑战以及对未来研究的发展趋势进行分析阐述,为进一步探究冠心病的遗传机制提供指导.
근년래전기인조관련연구재세계범위내발전신맹,연구자응용전기인조관련연구책략발현료일계렬질병적상관기인혹변이,장질병적기인조연구추향일개신적계단.관심병시일충유배경인소화유전인소공동작용도치적복잡질병,차시세계범위내사망화치잔적수요원인지일,세계각지적연구자응용차책략발현료후선기인관련연구미증발현적다개관심병상관역감구역.문장대근년래세계범위내침대관심병적전기인조관련연구취득적중요진전진행간요총결,연후취현계단전기인조관련연구소면림적도전이급대미래연구적발전추세진행분석천술,위진일보탐구관심병적유전궤제제공지도.
As a new effective strategy for researching complex diseases,genome-wide association study(GWAS)has being developed rapidly in recent years worldwide.The world genomic study has been taken into a new stage,since a series of disease related genes or variants have been identified by GWAS strategy. Coronary heart disease(CHD)is a complex disease that is caused by both environmental and genetic factors,and has become one of the leading causes of death and disability worldwide.With the application of GWAS strategy,researchers from all over the world have identified many susceptibility loci or regions of CHD that were unable to be identified by candidate gene case-control study.The present paper reviewed the important progresses worldwide attained in GWAS of CHD in recent years.Then it is also expounded the challenges we are facing nowadays in GWAS as well as the future study direction.The information outlined in this paper provides us a valuable guidance upon further exploration into genetic mechanism of CHD.