中国急救医学
中國急救醫學
중국급구의학
CHINESE JOURNAL OF CRITICAL CARE MEDICINE
2010年
2期
159-161
,共3页
郭欣%于永光%王丹%桑卓琦
郭訢%于永光%王丹%桑卓琦
곽흔%우영광%왕단%상탁기
急性有机磷农药中毒(AOPP)%胱抑素C(Cys C)%肾损伤%血液%尿液
急性有機燐農藥中毒(AOPP)%胱抑素C(Cys C)%腎損傷%血液%尿液
급성유궤린농약중독(AOPP)%광억소C(Cys C)%신손상%혈액%뇨액
Acute organophosphorus pesticide poisoning (AOPP)%Cystatin C%Renalinjury%Blood%Urine
目的 研究急性有机磷农药中毒(AOPP)患者血、尿胱抑素C(Cystatin C,Cys C)的变化及临床意义.方法 将41例AOPP患者根据中毒程度分为轻度AOPP组12例、中度AOPP组18例、重度AOPP组11例,选取对照组50例健康人分别做血、尿胱抑素C(Cys C)、血尿素氮(BUN)、血肌酐(SCr)和尿蛋白半定量(PRO)的检测,并进行对照分析.结果 轻度AOPP患者血、尿Cys C含量高于对照组(P<0.05);中、重度AOPP患者血、尿Cys C、血BUN、SCr均高于对照组(P<0.01);41例AOPP患者尿Cys C检测阳性率为100%,轻度AOPP患者尿蛋白半定量检测阳性率为16.7%,中度AOPP患者为66.7%.结论 血、尿Cys C可作为判断AOPP肾小球和肾小管早期受损的指标,较血BUN、SCr和尿蛋白半定量敏感,对AOPP早期肾损伤诊断及治疗有重要意义.
目的 研究急性有機燐農藥中毒(AOPP)患者血、尿胱抑素C(Cystatin C,Cys C)的變化及臨床意義.方法 將41例AOPP患者根據中毒程度分為輕度AOPP組12例、中度AOPP組18例、重度AOPP組11例,選取對照組50例健康人分彆做血、尿胱抑素C(Cys C)、血尿素氮(BUN)、血肌酐(SCr)和尿蛋白半定量(PRO)的檢測,併進行對照分析.結果 輕度AOPP患者血、尿Cys C含量高于對照組(P<0.05);中、重度AOPP患者血、尿Cys C、血BUN、SCr均高于對照組(P<0.01);41例AOPP患者尿Cys C檢測暘性率為100%,輕度AOPP患者尿蛋白半定量檢測暘性率為16.7%,中度AOPP患者為66.7%.結論 血、尿Cys C可作為判斷AOPP腎小毬和腎小管早期受損的指標,較血BUN、SCr和尿蛋白半定量敏感,對AOPP早期腎損傷診斷及治療有重要意義.
목적 연구급성유궤린농약중독(AOPP)환자혈、뇨광억소C(Cystatin C,Cys C)적변화급림상의의.방법 장41례AOPP환자근거중독정도분위경도AOPP조12례、중도AOPP조18례、중도AOPP조11례,선취대조조50례건강인분별주혈、뇨광억소C(Cys C)、혈뇨소담(BUN)、혈기항(SCr)화뇨단백반정량(PRO)적검측,병진행대조분석.결과 경도AOPP환자혈、뇨Cys C함량고우대조조(P<0.05);중、중도AOPP환자혈、뇨Cys C、혈BUN、SCr균고우대조조(P<0.01);41례AOPP환자뇨Cys C검측양성솔위100%,경도AOPP환자뇨단백반정량검측양성솔위16.7%,중도AOPP환자위66.7%.결론 혈、뇨Cys C가작위판단AOPP신소구화신소관조기수손적지표,교혈BUN、SCr화뇨단백반정량민감,대AOPP조기신손상진단급치료유중요의의.
Objective To study the changes and clinical significance of cystatin C (Cys C) in blood and urine of the patients with acute organophosphorus pesticide poisoning(AOPP).Methods To test and analyze cystatin C (Cys C)in blood and urine, blood urea nitrogen (BUN) , serum creatinine (SCr), semi- quantitative urinary protein (PRO) in 41 AOPP cases including 12 cases of mild poisoning group, 18 cases of moderate poisoning group, 11 cases of severe poisoning group, and the control group of 50 healthy people.Results The blood and urinary Cys C levels were higher in mild group than in control group, and the difference was statistically significant (P<0.05) ; the blood and urinary Cys C and serum BUN, SCr levels were higher in moderate and severe groups than in control group (P<0.01) ;positive rate of urinary Cys C in41 AOPP patients was 100%, positive rate of semi -quantitative urinary protein was 16.7% in mild AOPP patients and was 66.7% in moderate AOPP patients.Conclusion Blood and urinary Cys C could be used as an early indicator of glomerular and tubular damage in AOPP patients, and have higher sensitivity than blood BUN, SCr, semi - quantitative urine protein,and have an important significance in the diagnosis and treatment of early renal injury.
