国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2010年
6期
532-534
,共3页
血管内皮细胞生长因子%急性肺损伤%急性呼吸窘迫综合征
血管內皮細胞生長因子%急性肺損傷%急性呼吸窘迫綜閤徵
혈관내피세포생장인자%급성폐손상%급성호흡군박종합정
Vascular endothelial growth factor%Acute lung injury%Acute respiratory distresssyndrome
急性肺损伤(acute lurg injury,ALI)和急性呼吸窘迫综合征(acute respiratory distressyndrome,ARDS)的特征性病理改变为肺毛细血管通透性增高所致的肺水肿,血管内皮细胞生长因子能抗血管内皮细胞凋亡并增加血管通透性,可能在ALI和ARDS的病理过程中起到重要作用.现对血管内皮细胞生长因子在ALI中的作用进行综述,旨在为ALI和ARDS的治疗提供新的思路.
急性肺損傷(acute lurg injury,ALI)和急性呼吸窘迫綜閤徵(acute respiratory distressyndrome,ARDS)的特徵性病理改變為肺毛細血管通透性增高所緻的肺水腫,血管內皮細胞生長因子能抗血管內皮細胞凋亡併增加血管通透性,可能在ALI和ARDS的病理過程中起到重要作用.現對血管內皮細胞生長因子在ALI中的作用進行綜述,旨在為ALI和ARDS的治療提供新的思路.
급성폐손상(acute lurg injury,ALI)화급성호흡군박종합정(acute respiratory distressyndrome,ARDS)적특정성병리개변위폐모세혈관통투성증고소치적폐수종,혈관내피세포생장인자능항혈관내피세포조망병증가혈관통투성,가능재ALI화ARDS적병리과정중기도중요작용.현대혈관내피세포생장인자재ALI중적작용진행종술,지재위ALI화ARDS적치료제공신적사로.
Increased permeability and interstitial pulmonary edema are prominent features of acute lung injury (ALI)/acute respiratory distress syndrome(ARDS).Vascular endothelial cell growth factor(VEGF) has been identified by its properties to increase permeability and act as a cellular growth factor, thus it is a potential key role in the pathogenesis of ALI/ARDS. Understanding the role of VEGF in this disease process is crucial for developing new therapeutic strategies for ALI/ARDS.
